Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.6.1
Substance Class Protein
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
DW4CE8MKS9
Record Status Validated
Record Version
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Name Type Language Details References
AVDORALIMAB
Domain Jurisdiction Naming Organization
drug  
INN  
Official Name
English  
AVDORALIMAB [WHO-DD]
Common Name
English  
NNC-0215-0384
Code
English  
ANTI-C5AR-215
Common Name
English  
NN-8210
Code
English  
AVDORALIMAB [INN]
Common Name
English  
IPH-5401
Code
English  
IPH5401
Common Name
English  
Code System Code Type Description References
NCI_THESAURUS
C163020
Created by admin on Thu Nov 12 20:17:04 EST 2020 , Edited by admin on Thu Nov 12 20:17:04 EST 2020
PRIMARY
INN
11081
Created by admin on Thu Nov 12 20:17:04 EST 2020 , Edited by admin on Thu Nov 12 20:17:04 EST 2020
PRIMARY
CAS
2226393-85-5
Created by admin on Thu Nov 12 20:17:04 EST 2020 , Edited by admin on Thu Nov 12 20:17:04 EST 2020
PRIMARY
FDA UNII
DW4CE8MKS9
Created by admin on Thu Nov 12 20:17:04 EST 2020 , Edited by admin on Thu Nov 12 20:17:04 EST 2020
PRIMARY
From To
1_22 1_95
1_151 1_207
1_268 1_328
1_374 1_432
2_22 2_95
2_151 2_207
2_268 2_328
2_374 2_432
1_227 3_214
1_233 2_233
1_236 2_236
2_227 4_214
3_23 3_89
3_134 3_194
4_23 4_89
4_134 4_194
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_304
N 2_304
Related Record Type Details References
TARGET -> INHIBITOR
Mediator Substance Details
none
IPH5401 is a therapeutic human antibody that specifically binds and blocks C5a receptors (C5aR) expressed on subsets of myeloid-derived suppressor cells (MDSC) and neutrophils. IPH5401 blocks the binding of C5a to C5aR, thereby reducing the accumulation and activation of MDSC and neutrophils in tumors. Treatment with IPH5401 may unleash anti-tumor activities of T cells and NK cells.
Created by admin on Thu Nov 12 20:17:04 EST 2020 , Edited by admin on Thu Nov 12 20:17:04 EST 2020
Related Record Type Details References
ACTIVE MOIETY
none
Mediator Substance Details
none
Created by admin on Thu Nov 12 20:17:04 EST 2020 , Edited by admin on Thu Nov 12 20:17:04 EST 2020
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL 0
Note References
[Validation]WARNING:There are 4 substances with a similar sequence to subunit [3,4]:
(Perform similarity search on subunit [3])
found approximate duplicate (96%) sequence in Subunit [3] of "F0LZ415Z3B" ("TIXAGEVIMAB")
found approximate duplicate (96%) sequence in Subunit [4] of "F0LZ415Z3B" ("TIXAGEVIMAB")
found approximate duplicate (98%) sequence in Subunit [3] of "UP9K666A04" ("CAMIDANLUMAB")
found approximate duplicate (98%) sequence in Subunit [4] of "UP9K666A04" ("CAMIDANLUMAB")
Created Thu Nov 12 20:17:04 EST 2020
Created By admin
Last Edited Thu Nov 12 20:17:04 EST 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 WHO-DD WHO DRUG DICTIONARY
2 SYSTEM
3 STN STN (SCIFINDER)
4 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Nov 12 20:17:02 EST 2020
5 INN Proposed List 121 INN_LIST PUBLIC_DOMAIN_RELEASE
6 https://www.innate-pharma.com/en/pipeline/iph5401-first-class-anti-c5ar-mab MANUFACTURER PRODUCT DESCRIPTION PUBLIC_DOMAIN_RELEASE
7 https://adisinsight.springer.com/drugs/800036376 WEB PAGE
8 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Nov 12 20:17:02 EST 2020