Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.6.1
Substance Class Protein
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
5XO3JF0FEK
Record Status Validated
Record Version
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Name Type Language Details References
VIBOSTOLIMAB
Domain Jurisdiction Naming Organization
drug  
USAN   INN  
Official Name
English  
MK-7684
Code
English  
TIGIT INHIBITOR MK-7684
Code
English  
VIBOSTOLIMAB [USAN]
Common Name
English  
IMMUNOGLOBULIN G1, ANTI-(HUMAN RECEPTOR TIGIT (T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS)) (HUMAN-MUS MUSCULUS MONOCLONAL C011 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL C011 .KAPPA.-CHAIN, DIMER
Common Name
English  
IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS, V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 9, V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3)HUMANIZED MONOCLONAL ANTIBODY.GAMMA.1 HEAVY CHAIN HUMANI
Common Name
English  
TIGIT-TARGETING AGENT MK-7684
Code
English  
MK7684
Code
English  
VIBOSTOLIMAB [INN]
Common Name
English  
T-CELL IMMUNOGLOBULIN AND IMMUNORECEPTOR TYROSINE-BASED INHIBITORY MOTIF INHIBITOR MK-7684
Common Name
English  
Classification Tree Code System Code References
NCI_THESAURUS C141144
Created by admin on Thu Nov 12 23:01:26 EST 2020 , Edited by admin on Thu Nov 12 23:01:26 EST 2020
NCI_THESAURUS C129820
Created by admin on Thu Nov 12 23:01:26 EST 2020 , Edited by admin on Thu Nov 12 23:01:26 EST 2020
Code System Code Type Description References
CAS
2231305-30-7
Created by admin on Thu Nov 12 23:01:26 EST 2020 , Edited by admin on Thu Nov 12 23:01:26 EST 2020
PRIMARY
FDA UNII
5XO3JF0FEK
Created by admin on Thu Nov 12 23:01:26 EST 2020 , Edited by admin on Thu Nov 12 23:01:26 EST 2020
PRIMARY
INN
11178
Created by admin on Thu Nov 12 23:01:26 EST 2020 , Edited by admin on Thu Nov 12 23:01:26 EST 2020
PRIMARY
NCI_THESAURUS
C140041
Created by admin on Thu Nov 12 23:01:26 EST 2020 , Edited by admin on Thu Nov 12 23:01:26 EST 2020
PRIMARY
From To
1_22 1_96
2_22 2_96
2_146 2_202
2_222 4_214
2_263 2_323
1_146 1_202
2_369 2_427
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_222 3_214
1_228 2_228
1_231 2_231
1_263 1_323
1_369 1_427
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_299
N 2_299
Related Record Type Details References
TARGET -> INHIBITOR
none
none
Mediator Substance Details
none
Created by admin on Thu Nov 12 23:01:26 EST 2020 , Edited by admin on Thu Nov 12 23:01:26 EST 2020
Related Record Type Details References
ACTIVE MOIETY
none
Mediator Substance Details
none
Created by admin on Thu Nov 12 23:01:26 EST 2020 , Edited by admin on Thu Nov 12 23:01:26 EST 2020
Structural Modifications
Modification Type Location Site Location Type Residue Modified Extent Modification Name Modification ID
AMINO ACID REMOVAL C-TERMINUS LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL 0
Note References
[Validation]WARNING:There are 6 substances with a similar sequence to subunit [3,4]:
(Perform similarity search on subunit [3])
found approximate duplicate (95%) sequence in Subunit [4] of "3ZXZ2V0588" ("MONALIZUMAB")
found approximate duplicate (95%) sequence in Subunit [3] of "3ZXZ2V0588" ("MONALIZUMAB")
found approximate duplicate (95%) sequence in Subunit [3] of "DEW6X41BEK" ("TILDRAKIZUMAB")
found approximate duplicate (95%) sequence in Subunit [4] of "DEW6X41BEK" ("TILDRAKIZUMAB")
found approximate duplicate (96%) sequence in Subunit [4] of "6U3F28IT58" ("DEZAMIZUMAB")
found approximate duplicate (96%) sequence in Subunit [3] of "6U3F28IT58" ("DEZAMIZUMAB")
Created Thu Nov 12 23:01:26 EST 2020
Created By admin
Last Edited Thu Nov 12 23:01:26 EST 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Nov 12 23:01:21 EST 2020
2 USAN COUN 2020 USANCOUN NOMEN PUBLIC_DOMAIN_RELEASE
3 https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C140041 NCI THESAURUS PUBLIC_DOMAIN_RELEASE
4 INN Proposed List 121 INN_LIST PUBLIC_DOMAIN_RELEASE
5 SCIFINDER STN (SCIFINDER) NOMEN PUBLIC_DOMAIN_RELEASE
6 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Nov 12 23:01:21 EST 2020