Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.7.1
Substance Class Chemical
Record UNII
UE5K2FNS92
Record Status Validated
Record Version
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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H17N3O2
Molecular Weight 307.3465
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0
Created by admin on Sat Jun 26 06:10:04 EDT 2021
Edited by GUEST on Wed Jul 21 15:50:16 EDT 2021
Structure of ORTERONEL

Systematic Names:

  • None recorded

SMILES

CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)[C@@]3(O)CCN4C=NC=C34

InChI

OZPFIJIOIVJZMN-SFHVURJKSA-N
InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)/t18-/m0/s1
Name Type Language Details Access References
ORTERONEL
Domain Jurisdiction Naming Organization
drug  
INN   USAN  
INN   USAN   WHO-DD  
Official Name
English  
TAK-700
Code
English  
ORTERONEL [WHO-DD]
Common Name
English  
ORTERONEL [USAN]
Common Name
English  
ORTERONEL [JAN]
Common Name
English  
ORTERONEL [INN]
Common Name
English  
6-((7S)-7-HYDROXY-6,7-DIHYDRO-5H-PYRROLO(1,2-C)IMIDAZOL-7-YL)-N-METHYL-2-NAPHTHALENECARBOXAMIDE
Systematic Name
English  
2-NAPHTHALENECARBOXAMIDE, 6-((7S)-6,7-DIHYDRO-7-HYDROXY-5H-PYRROLO(1,2-C)IMIDAZOL-7-YL)-N-METHYL-
Systematic Name
English  
Classification Tree Code System Code Access References
NCI_THESAURUS C471
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
Code System Code Type Description Access References
CAS
426219-18-3
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
NON-SPECIFIC STEREOCHEMISTRY
CAS
566939-85-3
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
EVMPD
SUB126331
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
ChEMBL
CHEMBL1921976
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
DRUG BANK
DB12066
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
FDA UNII
UE5K2FNS92
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
INN
9332
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
MESH
C571806
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
NCI_THESAURUS
C90582
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
PUBCHEM
9796590
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
WIKIPEDIA
ORTERONEL
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
PRIMARY
Related Record Type Details Access References
TARGET -> INHIBITOR
Mediator Substance Details
none
Inhibition of CYP17 activity thus decreases circulating levels of testosterone
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
Related Record Type Details Access References
ACTIVE MOIETY
none
none
Mediator Substance Details
none
Created by admin on Sat Jun 26 06:10:04 EDT 2021 , Edited by admin on Sat Jun 26 06:10:04 EDT 2021
Created Sat Jun 26 06:10:04 EDT 2021
Created By admin
Last Edited Sat Jun 26 06:10:04 EDT 2021
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File Access
1 STN (SCIFINDER) STN (SCIFINDER) NOMEN
2 SRS import [UE5K2FNS92] SRS NOMEN Fri Apr 28 14:52:07 EDT 2017
3 WHO-DD SRS NOMEN
4 ORTERONEL [WHO-DD] SRS_LOCATOR
5 STN SRS NOMEN PUBLIC_DOMAIN_RELEASE AUTO_SELECTED
6 STN STN (SCIFINDER)
7 STN STN (SCIFINDER)
8 USAN COUN 2011 USANCOUN NOMEN PUBLIC_DOMAIN_RELEASE
9 SYSTEM
10 SRS CODE IMPORT SRS NOMEN Fri Apr 28 14:52:07 EDT 2017
11 USAN SRS NOMEN
12 ORTERONEL [USAN] SRS_LOCATOR
13 CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY [1040-8428] ROVIELLO, GIANDOMENICO YR:2016 VOL:101 PG:12 -20 JOURNAL ARTICLE NOMEN
14 dump-public-2021-06-23_UPDATED.gsrs BATCH_IMPORT Sat Jun 26 06:10:01 EDT 2021
15 INN Proposed List 104 INN_LIST PUBLIC_DOMAIN_RELEASE
16 INN SRS NOMEN
17 ORTERONEL [INN] SRS_LOCATOR
18 JAN SRS PUBLIC_DOMAIN_RELEASE NOMEN

Molecular Formula C18H17N3O2
Molecular Weight 307.3465
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED