Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.7.1
Substance Class Protein
Protein Type ENZYME
Protein Sub Type CYTOCHROME P450
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
PUO0521HZV
Record Status Validated
Record Version
Show Definitional References Hide Definitional References
Download
Name Type Language Details Access References
CYTOCHROME P450 3A4
Common Name
English  
NIFEDIPINE OXIDASE
Common Name
English  
HUMAN CYTOCHROME P450 3A4
Common Name
English  
CYTOCHROME P 450 3A4
Common Name
English  
CYP3A4
Common Name
English  
CHOLESTEROL 25-HYDROXYLASE
Common Name
English  
ALBENDAZOLE MONOOXYGENASE
Common Name
English  
Code System Code Type Description Access References
CAS
329736-03-0
Created by admin on Wed Aug 04 04:41:24 EDT 2021 , Edited by admin on Wed Aug 04 04:41:24 EDT 2021
PRIMARY
EVMPD
SUB182775
Created by admin on Wed Aug 04 04:41:24 EDT 2021 , Edited by admin on Wed Aug 04 04:41:24 EDT 2021
PRIMARY
EC (ENZYME CLASS)
EC 1.14.13.67
Created by admin on Wed Aug 04 04:41:24 EDT 2021 , Edited by admin on Wed Aug 04 04:41:24 EDT 2021
PRIMARY
FDA UNII
PUO0521HZV
Created by admin on Wed Aug 04 04:41:24 EDT 2021 , Edited by admin on Wed Aug 04 04:41:24 EDT 2021
PRIMARY
UNIPROT
P08684
Created by admin on Wed Aug 04 04:41:24 EDT 2021 , Edited by admin on Wed Aug 04 04:41:24 EDT 2021
PRIMARY
Related Record Type Details Access References
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
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MAJOR
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
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Mediator Substance Details
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Created by admin on Wed Aug 04 04:41:31 EDT 2021 , Edited by admin on Wed Aug 04 04:41:31 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
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MAJOR
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
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Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
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MAJOR
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
INHIBITOR -> TARGET
none
Mediator Substance Details
none
PHARMAKINETIC ENHANCER
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
Mediator Substance Details
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Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
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MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
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TIME-DEPENDENT INHIBITION
WEAK
Ki
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
Tenapanor is a substrate of CYP3A4 and CYP3A5; however, none of the CYP enzymes was found to be responsible for ?25% of its overall elimination.
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
IN VITRO
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
NON-SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 06:40:16 EDT 2021 , Edited by admin on Wed Aug 04 06:40:16 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
In vivo, the sum of enzalutamide and M2 exposure was increased by 2.2-fold and 1.3-fold when it was co-administered with gemfibrozil (strong CYP2C8 inhibitor) or itraconazole (strong CYP3A4 inhibitor), respectively.
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
IC50
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 17:13:29 EDT 2021 , Edited by admin on Wed Aug 04 17:13:29 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
NON-SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
Drugs that induce or inhibit CYP3A, P-gp, and BCRP may affect temsavir plasma concentrations.
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
NON-INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
INDUCER -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
IRREVERSIBLE INHIBITOR
Unit K inact(min-1)
k(inactivation)
Created by admin on Wed Aug 04 04:41:45 EDT 2021 , Edited by admin on Wed Aug 04 04:41:45 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:30 EDT 2021 , Edited by admin on Wed Aug 04 04:41:30 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
Mediator Substance Details
none
The following dose modifications are recommended: Strong CYP3A inhibitors: Reduce dose to 250 mg QD
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
INDUCER -> METABOLIC ENZYME
Mediator Substance Details
none
The induction of CYP3A4 enzyme (3.9 times) was lower than the mRNA increase (65 times), indicating possible time-dependent inhibition.
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
Midazolam is the substrate.
Created by admin on Wed Aug 04 07:53:12 EDT 2021 , Edited by admin on Wed Aug 04 07:53:12 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
IC50
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
INDUCER -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:42 EDT 2021 , Edited by admin on Wed Aug 04 04:41:42 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
Strong CYP3A inhibitor: co-administration of itraconazole, a strong CYP3A and P-gp inhibitor, increased gilteritinib systemic exposure by approximately 2.2- fold. Moderate CYP3A inhibitor: coadministration of fluconazole, a moderate CYP3A inhibitor, increased gilteritinib systemic exposure by approximately 1.4-fold.
IC50
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
In an in-vitro study, eluxadoline appears to show time-dependent inhibition of CYP3A4 at 50 ?M, a concentration that can be achieved in the gut (Igut is estimated to be 700 ?M).
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
POTENT
Created by admin on Wed Aug 04 04:41:44 EDT 2021 , Edited by admin on Wed Aug 04 04:41:44 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
WEAK
Lomitapide is a weak in vivo CYP3A inhibitor.
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
INDUCER -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
CYP3A4 in the total clearance of erdafitinib is estimated to be 20%.
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Co-administration with rifampin (P-gp and strong CYP3A inducer) decreased the AUC and Cmax of relugolix by 55% and 23%, respectively.
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
NON-SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
high stability to human CYP4503A4 (85% remaining)
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
MAJOR
The following dose modifications are recommended: Sensitive CYP3A substrates: Avoid concomitant use.
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
moderate and strong inducers of CYP3A4 should not be co-administered due to the potential for loss of efficacy.
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
INDUCER -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:46 EDT 2021 , Edited by admin on Wed Aug 04 04:41:46 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 12:28:47 EDT 2021 , Edited by admin on Wed Aug 04 12:28:47 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
RESPONSIBLE FOR 90 PERCENT OF METABOLISM
Created by admin on Wed Aug 04 07:53:12 EDT 2021 , Edited by admin on Wed Aug 04 07:53:12 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:33 EDT 2021 , Edited by admin on Wed Aug 04 04:41:33 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
IN VITRO
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
STRONG
sensitive substrates of CYP3A4 with a narrow therapeutic index should not be coadministered.
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
INDUCER -> METABOLIC ENZYME
Mediator Substance Details
none
Tafamidis induced CYP3A4 in vitro with an EC50 of 28 ?M.
EC50
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:34 EDT 2021 , Edited by admin on Wed Aug 04 04:41:34 EDT 2021
INDUCER -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
MINOR
Inhibitor at higher concentrations than are clinically achieved.
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
METABOLIC ENZYME -> SUBSTRATE
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
POTENT
Created by admin on Wed Aug 04 04:41:37 EDT 2021 , Edited by admin on Wed Aug 04 04:41:37 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:35 EDT 2021 , Edited by admin on Wed Aug 04 04:41:35 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:27 EDT 2021 , Edited by admin on Wed Aug 04 04:41:27 EDT 2021
INDUCER -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
INDUCER -> METABOLIC ENZYME
Mediator Substance Details
none
IC50
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:28 EDT 2021 , Edited by admin on Wed Aug 04 04:41:28 EDT 2021
INDUCER -> METABOLIC ENZYME
Mediator Substance Details
none
POTENT
Created by admin on Wed Aug 04 04:41:39 EDT 2021 , Edited by admin on Wed Aug 04 04:41:39 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
TIME-DEPENDENT INHIBITION
Lonafarnib is a potent CYP3A time-dependent and mechanism-based inhibitor.
POTENCY
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
CYP3A4 showed no preference between the two enantiomers
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
ANIMAL ORTHOLOG->HUMAN ORTHOLOG
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 23:54:48 EDT 2021 , Edited by admin on Wed Aug 04 23:54:48 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MINOR
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 07:19:35 EDT 2021 , Edited by admin on Wed Aug 04 07:19:35 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
NON-SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
REVERSIBLE
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
6?-hydroxylation of testosterone
IC50
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
INDUCER -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
In vitro, ozenoxacin caused mild inhibition of CYP3A4 and CYP2C9 at high concentrations (?100 ?M).
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
INDUCER -> METABOLIC ENZYME
Mediator Substance Details
none
strong CYP3A4 induction in a concentration-dependent manner
MAY BE CLINICALLY SIGNIFICANT
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:34 EDT 2021 , Edited by admin on Wed Aug 04 04:41:34 EDT 2021
NON-INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:25 EDT 2021 , Edited by admin on Wed Aug 04 04:41:25 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
in vitro studies utilizing human liver microsomes show that zafirlukast inhibits the cytochrome P450 CYP3A4 and CYP2C9 isoenzymes at concentrations close to the clinically achieved total plasma concentrations.
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:28 EDT 2021 , Edited by admin on Wed Aug 04 04:41:28 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
WEAK INHIBITION
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
NON-INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
NO INHIBITION AT 160 TIMES CMAX
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
TISSUE EXPRESSION -> PARENT
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
Coadministration of multiple doses of larotrectinib with a sensitive CYP3A4 substrate (midazolam) increased the AUCinf and Cmax of midazolam by 1.7-fold as compared to midazolam administered alone.
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
METABOLIC ENZYME -> INHIBITOR
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:24 EDT 2021 , Edited by admin on Wed Aug 04 04:41:24 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 07:04:15 EDT 2021 , Edited by admin on Wed Aug 04 07:04:15 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
INDUCER -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
COMPETITIVE INHIBITOR
Ki
Created by admin on Wed Aug 04 04:41:45 EDT 2021 , Edited by admin on Wed Aug 04 04:41:45 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Alosetron is metabolized by human microsomal cytochrome P450 (CYP), shown in vitro to involve enzymes 2C9 (30%), 3A4 (18%), and 1A2 (10%).
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
INDUCER -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
IC50
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
Coadministration of BIC (given without F/TAF) with rifampin decreased the mean BIC Cmax and AUC by 28% and 75%, respectively.
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:59 EDT 2021 , Edited by admin on Wed Aug 04 04:41:59 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
SELECTIVE
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
INDUCER -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:33 EDT 2021 , Edited by admin on Wed Aug 04 04:41:33 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:41 EDT 2021 , Edited by admin on Wed Aug 04 04:41:41 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 05:17:36 EDT 2021 , Edited by admin on Wed Aug 04 05:17:36 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
TIME-DEPENDENT INHIBITION
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
INDUCER -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:33 EDT 2021 , Edited by admin on Wed Aug 04 04:41:33 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 11:01:52 EDT 2021 , Edited by admin on Wed Aug 04 11:01:52 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
Fidaxomicin and OP-1118 exhibited inhibitory potential for prominent intestinal CYP isoenzymes (CYP3A4, CYP2C9, and CYP2C19) in in vitro studies with human liver microsomes, based on estimated intestinal concentrations (fidaxomicin [I]2, 800 ?g/mL).
IC50
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
TIME-DEPENDENT INHIBITION
In vitro, avapritinib is a time-dependent inhibitor as well as an inducer of CYP3A.
Ki
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
INDUCER -> METABOLIC ENZYME
Mediator Substance Details
none
WEAK
Zanubrutinib is a weak inducer of CYP3A4 and CYP2C19 in vivo.
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
WEAK
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:56 EDT 2021 , Edited by admin on Wed Aug 04 04:41:56 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:48 EDT 2021 , Edited by admin on Wed Aug 04 04:41:48 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
IC50
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
NON-SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:55 EDT 2021 , Edited by admin on Wed Aug 04 04:41:55 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:57 EDT 2021 , Edited by admin on Wed Aug 04 04:41:57 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:52 EDT 2021 , Edited by admin on Wed Aug 04 04:41:52 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:54 EDT 2021 , Edited by admin on Wed Aug 04 04:41:54 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
Mediator Substance Details
none
MAJOR
Created by admin on Wed Aug 04 04:41:58 EDT 2021 , Edited by admin on Wed Aug 04 04:41:58 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
INHIBITOR -> METABOLIC ENZYME
Mediator Substance Details
none
Eribulin inhibited CYP3A4 activity with an apparent inhibition constant (Ki) value ranging from 3 ?M to 30 ?M (2190 ng/mL to 21,900 ng/mL), and the inhibition was demonstrated to be reversible and competitive.
Ki
Created by admin on Wed Aug 04 04:41:53 EDT 2021 , Edited by admin on Wed Aug 04 04:41:53 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:50 EDT 2021 , Edited by admin on Wed Aug 04 04:41:50 EDT 2021
SUBSTRATE -> METABOLIC ENZYME
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:51 EDT 2021 , Edited by admin on Wed Aug 04 04:41:51 EDT 2021
INHIBITOR -> METABOLIC ENZYME
none
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 04:41:49 EDT 2021 , Edited by admin on Wed Aug 04 04:41:49 EDT 2021