Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.7.1
Substance Class Protein
Protein Type PEPTIDE
Protein Sub Type
Sequence Type COMPLETE
Record UNII
TO3JYR3BOU
Record Status Validated
Record Version
Show Definitional References Hide Definitional References
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Name Type Language Details Access References
PEGCETACOPLAN
Domain Jurisdiction Naming Organization
drug  
INN   USAN  
Official Name
English  
POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-HYDRO-.OMEGA.-HYDROXY-, 15,15'-DIESTER WITH N-ACETYL-L-ISOLEUCYL-L-CYSTEINYL-L-VALYL-1-METHYL-L-TRYPTOPHYL-L-GLUTAMINYL-L-.ALPHA.-ASPARTYL-L-TRYPTOPHYLGLYCYL-L-ALANYL-L-HISTIDYL-L-ARGINYL-L-CYSTEINYL-L-THREONYL-2-(2-(2-AMINOETHOXY)ETHOXY)ACETYL-N6-CARBOXY-L-LYSINAMIDE CYCLIC (2->12)-(DISULFIDE)
Systematic Name
English  
PEGCETACOPLAN [USAN]
Common Name
English  
PEGCETACOPLAN [INN]
Common Name
English  
O,O'-BIS((S2,S12-CYCLO(N-ACETYL-L-ISOLEUCYL-L-CYSTEINYL-L-VALYL-1-METHYL-L-TRYPTOPHYL-L-GLUTAMINYL-L-.ALPHA.-ASPARTYL-L-TRYPTOPHYLGLYCYL-L-ALANYL-L-HISTIDYL-L-ARGINYL-L-CYSTEINYL-L-THREONYL-2-(2-(2-AMINOETHOXY)ETHOXY)ACETYL-L-LYSINAMIDE))-N6.15-CARBONYL)POLYETHYLENE GLYCOL (N = 800-1100)
Systematic Name
English  
EMPAVELI
Brand Name
English  
APL-2
Code
English  
Classification Tree Code System Code Access References
FDA ORPHAN DRUG 627018
Created by admin on Wed Aug 04 03:59:58 EDT 2021 , Edited by admin on Wed Aug 04 03:59:58 EDT 2021
FDA ORPHAN DRUG 633418
Created by admin on Wed Aug 04 03:59:58 EDT 2021 , Edited by admin on Wed Aug 04 03:59:58 EDT 2021
Code System Code Type Description Access References
CAS
2019171-69-6
Created by admin on Wed Aug 04 03:59:58 EDT 2021 , Edited by admin on Wed Aug 04 03:59:58 EDT 2021
PRIMARY
EVMPD
SUB195466
Created by admin on Wed Aug 04 03:59:58 EDT 2021 , Edited by admin on Wed Aug 04 03:59:58 EDT 2021
PRIMARY
FDA ORPHAN DRUG
427614
Created by admin on Wed Aug 04 03:59:58 EDT 2021 , Edited by admin on Wed Aug 04 03:59:58 EDT 2021
PRIMARY
FDA UNII
TO3JYR3BOU
Created by admin on Wed Aug 04 03:59:58 EDT 2021 , Edited by admin on Wed Aug 04 03:59:58 EDT 2021
PRIMARY
INN
10743
Created by admin on Wed Aug 04 03:59:58 EDT 2021 , Edited by admin on Wed Aug 04 03:59:58 EDT 2021
PRIMARY
NCI_THESAURUS
C170296
Created by admin on Wed Aug 04 03:59:58 EDT 2021 , Edited by admin on Wed Aug 04 03:59:58 EDT 2021
PRIMARY
From To
1_2 1_12
2_2 2_12
Related Record Type Details Access References
ACTIVE MOIETY
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 03:59:58 EDT 2021 , Edited by admin on Wed Aug 04 03:59:58 EDT 2021
Structural Modifications
Modification Type Location Site Location Type Residue Modified Extent Modification Name Modification ID Access
AMINO_ACID_SUBSTITUTION [1_4] [2_4] SITE_SPECIFIC 1-METHYL-L-TRYPTOPHAN XD0FY1J13B
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS N-ACETYLISOLEUCINE P9CL0Y0BVZ
PEGYLATION [1_14] [2_14] C-TERMINUS PEGCETACOPLAN LYSINE MODIFICATION P1K5L81WUZ
Name Property Type Amount Referenced Substance Defining Parameters Access References
Molecular Formula CHEMICAL
0
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
0
Created Wed Aug 04 03:59:58 EDT 2021
Created By admin
Last Edited Wed Aug 04 03:59:58 EDT 2021
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File Access
1 EVMPD EVMPD PUBLIC_DOMAIN_RELEASE NOMEN
2 USAN COUN 2019 USANCOUN NOMEN PUBLIC_DOMAIN_RELEASE
3 STN STN (SCIFINDER)
4 dump-public-2021-07-22_UPDATED.gsrs BATCH_IMPORT Wed Aug 04 03:59:56 EDT 2021
5 https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/215014s000lbl.pdf DRUGS@FDA PUBLIC_DOMAIN_RELEASE
6 https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=427614 ORPHAN DRUG PUBLIC_DOMAIN_RELEASE NOMEN
7 Liao, David S., et al. "Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: A randomized phase 2 trial." Ophthalmology (2019). JA CLIN POT
8 INN Proposed List 120 INN_LIST PUBLIC_DOMAIN_RELEASE
9 FDA_SRS STN (SCIFINDER)