Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.7.1
Substance Class Chemical
Record UNII
E0YF0M8O09
Record Status Validated
Record Version
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Details

Stereochemistry ACHIRAL
Molecular Formula C22H23F3N8O
Molecular Weight 472.4662
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0
Created by admin on Wed Aug 04 01:58:33 EDT 2021
Edited by admin on Wed Aug 04 01:58:33 EDT 2021
Structure of DAROVASERTIB

Systematic Names:

  • None recorded

SMILES

CC1(N)CCN(CC1)C2=CC=CN=C2NC(=O)C3=C(N)N=CC(=N3)C4=C(C=CC=N4)C(F)(F)F

InChI

XXJXHXJWQSCNPX-UHFFFAOYSA-N
InChI=1S/C22H23F3N8O/c1-21(27)6-10-33(11-7-21)15-5-3-9-29-19(15)32-20(34)17-18(26)30-12-14(31-17)16-13(22(23,24)25)4-2-8-28-16/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34)
Name Type Language Details Access References
DAROVASERTIB
Domain Jurisdiction Naming Organization
drug  
INN   USAN  
Official Name
English  
NVP-LXS-196
Code
English  
LXS196
Code
English  
LXS-196
Code
English  
IDE196
Code
English  
IDE-196
Code
English  
DAROVASERTIB [USAN]
Common Name
English  
DAROVASERTIB [INN]
Common Name
English  
3-AMINO-N-(3-(4-AMINO-4-METHYLPIPERIDIN-1-YL)PYRIDIN-2-YL)-6-(3-(TRIFLUOROMETHYL)PYRIDIN-2-YL)PYRAZINE-2-CARBOXAMIDE
Systematic Name
English  
2-PYRAZINECARBOXAMIDE, 3-AMINO-N-(3-(4-AMINO-4-METHYL-1-PIPERIDINYL)-2-PYRIDINYL)-6-(3-(TRIFLUOROMETHYL)-2-PYRIDINYL)-
Systematic Name
English  
Code System Code Type Description Access References
CAS
1874276-76-2
Created by admin on Wed Aug 04 01:58:33 EDT 2021 , Edited by admin on Wed Aug 04 01:58:33 EDT 2021
PRIMARY
FDA UNII
E0YF0M8O09
Created by admin on Wed Aug 04 01:58:33 EDT 2021 , Edited by admin on Wed Aug 04 01:58:33 EDT 2021
PRIMARY
INN
11415
Created by admin on Wed Aug 04 01:58:33 EDT 2021 , Edited by admin on Wed Aug 04 01:58:33 EDT 2021
PRIMARY
NCI_THESAURUS
C124796
Created by admin on Wed Aug 04 01:58:33 EDT 2021 , Edited by admin on Wed Aug 04 01:58:33 EDT 2021
PRIMARY
PUBCHEM
118873253
Created by admin on Wed Aug 04 01:58:33 EDT 2021 , Edited by admin on Wed Aug 04 01:58:33 EDT 2021
PRIMARY
Related Record Type Details Access References
TARGET -> INHIBITOR
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 01:58:33 EDT 2021 , Edited by admin on Wed Aug 04 01:58:33 EDT 2021
Related Record Type Details Access References
ACTIVE MOIETY
none
Mediator Substance Details
none
Created by admin on Wed Aug 04 01:58:33 EDT 2021 , Edited by admin on Wed Aug 04 01:58:33 EDT 2021
Created Wed Aug 04 01:58:33 EDT 2021
Created By admin
Last Edited Wed Aug 04 01:58:33 EDT 2021
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File Access
1 SRS SRS NOMEN
2 dump-public-2021-07-22_UPDATED.gsrs BATCH_IMPORT Wed Aug 04 01:58:30 EDT 2021
3 Fischer, Peter M. "Approved and Experimental Small?Molecule Oncology Kinase Inhibitor Drugs: A Mid?2016 Overview." Medicinal research reviews 37.2 (2017): 314-367. JA
4 SRS import [E0YF0M8O09] SRS NOMEN Fri Apr 28 15:28:55 EDT 2017
5 USAN COUN 2021 USANCOUN PUBLIC_DOMAIN_RELEASE
6 PUBCHEM NLM NOMEN PUBLIC_DOMAIN_RELEASE
7 INN Proposed List 123 INN_LIST PUBLIC_DOMAIN_RELEASE
8 NCIT NCI THESAURUS
9 NCI THESAURUS NCI THESAURUS NOMEN PUBLIC_DOMAIN_RELEASE
10 SCIFINDER STN (SCIFINDER) NOMEN PUBLIC_DOMAIN_RELEASE
11 https://adisinsight.springer.com/drugs/800043872 WEBSITE NOMEN PUBLIC_DOMAIN_RELEASE

Molecular Formula C22H23F3N8O
Molecular Weight 472.4662
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE