{"created":1786418515776,"createdBy":"ADMIN","lastEdited":1786418515776,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"df572e05-b6f7-4fc9-9ba7-977a06dcfbb8","definitionType":"PRIMARY","definitionLevel":"COMPLETE","substanceClass":"chemical","status":"approved","version":"24","approvedBy":"FDA_SRS","approvalID":"7ZW40D021M","structure":{"id":"d52f3e18-3fac-1000-6421-0fee575f5710","created":1786418515787,"lastEdited":1786418515794,"deprecated":false,"digest":"78c42ab3eb48cccd368d44735649fe7aae8799a3","molfile":"\n Marvin 01132111032D \n\n 66 76 0 0 1 0 999 V2000\n 18.2461 -8.4556 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 19.0711 -8.4556 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 18.9278 -7.6432 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 19.5598 -7.1128 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 18.9278 -6.5826 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 19.9723 -6.3984 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 20.3351 -7.3950 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 20.4783 -8.2075 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 19.8463 -8.7378 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 18.9278 -9.2680 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n 17.8336 -9.1700 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.0086 -9.1700 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 16.5961 -8.4556 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.0086 -7.7411 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 16.4566 -7.1280 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.7028 -7.4636 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 14.9884 -7.0511 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 14.9884 -6.2261 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 14.2740 -5.8136 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 14.2740 -4.9886 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 14.9884 -4.5761 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.1599 -3.7691 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 15.9804 -3.6829 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 16.3929 -2.9684 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.2179 -2.9684 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.6304 -2.2540 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 18.4554 -2.2540 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.2179 -1.5395 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.6304 -0.8250 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0\n 16.3929 -1.5395 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.9804 -2.2540 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.9804 -0.8250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 16.3160 -4.4366 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.7028 -4.9886 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.7028 -5.8136 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 16.4174 -6.2261 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.1230 -4.6081 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 17.7360 -4.0560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 18.4505 -4.4685 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 18.2790 -5.2755 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.4585 -5.3617 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 19.2042 -4.1330 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 19.8716 -4.6179 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 20.6253 -4.2823 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 21.3790 -4.6179 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 21.9310 -4.0049 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 21.5185 -3.2903 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 20.7115 -3.4619 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 20.0441 -2.9770 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 19.2904 -3.3125 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 21.8540 -2.5367 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 19.7853 -5.4384 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0\n 17.6498 -3.2356 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 14.2740 -7.4636 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 15.7891 -8.2840 0.0000 N 0 0 2 0 0 0 0 0 0 0 0 0\n 15.1761 -8.8361 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 14.5259 -8.3282 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 14.4111 -9.1451 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 13.9032 -9.7952 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.6133 -9.5357 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 16.4362 -9.5933 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 16.6358 -10.3937 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.9362 -10.8309 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 15.3041 -10.3007 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 17.4007 -10.7028 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 17.8336 -7.7411 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 0 0 0 0\n 2 3 1 0 0 0 0\n 4 3 1 0 0 0 0\n 4 5 1 0 0 0 0\n 4 6 1 0 0 0 0\n 7 4 1 0 0 0 0\n 7 8 1 0 0 0 0\n 8 9 1 0 0 0 0\n 9 2 1 0 0 0 0\n 2 10 1 1 0 0 0\n 1 11 1 0 0 0 0\n 11 12 2 0 0 0 0\n 13 12 1 0 0 0 0\n 13 14 2 0 0 0 0\n 15 14 1 0 0 0 0\n 16 15 2 0 0 0 0\n 17 16 1 0 0 0 0\n 18 17 1 0 0 0 0\n 18 19 1 0 0 0 0\n 20 19 1 0 0 0 0\n 21 20 1 0 0 0 0\n 21 22 2 0 0 0 0\n 22 23 1 0 0 0 0\n 24 23 1 0 0 0 0\n 24 25 2 0 0 0 0\n 26 25 1 0 0 0 0\n 26 27 1 0 0 0 0\n 28 26 2 0 0 0 0\n 28 29 1 0 0 0 0\n 28 30 1 0 0 0 0\n 31 30 2 0 0 0 0\n 31 24 1 0 0 0 0\n 30 32 1 0 0 0 0\n 23 33 1 0 0 0 0\n 33 34 2 0 0 0 0\n 35 34 1 0 0 0 0\n 18 35 1 0 0 0 0\n 35 36 1 6 0 0 0\n 21 34 1 0 0 0 0\n 37 33 1 0 0 0 0\n 37 38 1 0 0 0 0\n 38 39 1 0 0 0 0\n 39 40 1 0 0 0 0\n 41 40 2 0 0 0 0\n 37 41 1 0 0 0 0\n 42 39 1 0 0 0 0\n 42 43 2 0 0 0 0\n 43 44 1 0 0 0 0\n 45 44 1 0 0 0 0\n 46 45 2 0 0 0 0\n 46 47 1 0 0 0 0\n 47 48 1 0 0 0 0\n 49 48 1 0 0 0 0\n 49 50 2 0 0 0 0\n 42 50 1 0 0 0 0\n 48 44 2 0 0 0 0\n 47 51 1 0 0 0 0\n 52 43 1 0 0 0 0\n 38 53 2 0 0 0 0\n 17 54 2 0 0 0 0\n 55 16 1 0 0 0 0\n 13 55 1 0 0 0 0\n 56 55 1 6 0 0 0\n 56 57 1 0 0 0 0\n 57 58 1 0 0 0 0\n 56 58 1 0 0 0 0\n 58 59 1 1 0 0 0\n 56 60 1 0 0 0 0\n 60 61 1 0 0 0 0\n 62 61 1 0 0 0 0\n 62 63 1 0 0 0 0\n 64 63 1 0 0 0 0\n 64 60 2 0 0 0 0\n 62 65 2 0 0 0 0\n 66 14 1 0 0 0 0\n 1 66 2 0 0 0 0\nM END","smiles":"Cc1cc(cc(C)c1F)-n2c(c3[C@H](C)N(CCc3n2)C(=O)c4cc5cc(ccc5n4[C@]6(C[C@@H]6C)c7[nH]c(=O)on7)[C@@]8([H])CCOC(C)(C)C8)-n9ccn(-c%10ccc%11c(cnn%11C)c%10F)c9=O","formula":"C48H48F2N10O5","opticalActivity":"UNSPECIFIED","atropisomerism":"No","stereoCenters":4,"definedStereo":4,"ezCenters":0,"charge":0,"mwt":882.9573,"count":1,"createdBy":"ADMIN","lastEditedBy":"ADMIN","stereochemistry":"ABSOLUTE","access":[],"references":["1c78eaa1-3ff7-4b1d-9297-3d3fbe18f7b2","41ee8b82-c75d-51d3-c8a9-43e578363534"],"_inchiKey":"USUWIEBBBWHKNI-KHIFEHGGSA-N","_inchi":"InChI=1S/C48H48F2N10O5/c1-25-18-32(19-26(2)40(25)49)60-42(58-16-15-57(46(58)63)37-11-10-36-33(41(37)50)24-51-55(36)7)39-28(4)56(14-12-34(39)53-60)43(61)38-21-31-20-29(30-13-17-64-47(5,6)23-30)8-9-35(31)59(38)48(22-27(48)3)44-52-45(62)65-54-44/h8-11,15-16,18-21,24,27-28,30H,12-14,17,22-23H2,1-7H3,(H,52,54,62)/t27-,28-,30-,48-/m0/s1","hash":"USUWIEBBBWHKNI_KHIFEHGGSA_N"},"_name":"Orforglipron","_approvalIDDisplay":"7ZW40D021M","access":[],"_self":"https://gsrs.ncats.nih.gov/api/v1/substances(df572e05-b6f7-4fc9-9ba7-977a06dcfbb8)?view=full","_moieties":{"count":1,"url":"https://gsrs.ncats.nih.gov/api/v1/substances(df572e05-b6f7-4fc9-9ba7-977a06dcfbb8)/moieties"},"_names":{"count":9,"url":"https://gsrs.ncats.nih.gov/api/v1/substances(df572e05-b6f7-4fc9-9ba7-977a06dcfbb8)/names"},"_codes":{"count":8,"url":"https://gsrs.ncats.nih.gov/api/v1/substances(df572e05-b6f7-4fc9-9ba7-977a06dcfbb8)/codes"},"_properties":{"count":0,"url":"https://gsrs.ncats.nih.gov/api/v1/substances(df572e05-b6f7-4fc9-9ba7-977a06dcfbb8)/properties"},"_relationships":{"count":4,"url":"https://gsrs.ncats.nih.gov/api/v1/substances(df572e05-b6f7-4fc9-9ba7-977a06dcfbb8)/relationships"},"_references":{"count":10,"url":"https://gsrs.ncats.nih.gov/api/v1/substances(df572e05-b6f7-4fc9-9ba7-977a06dcfbb8)/references"}}