{"created":1786434701937,"createdBy":"ADMIN","lastEdited":1786434701937,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"a2364b6f-b9b0-4b56-bd2a-9b823f7909ca","definitionType":"PRIMARY","definitionLevel":"COMPLETE","substanceClass":"protein","status":"approved","version":"5","approvedBy":"FDA_SRS","names":[{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"bb5b941f-7d22-4a5d-9461-3019d6a98200","name":"LEAP-2","stdName":"LEAP-2","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["802d0c22-efd1-4a97-b481-81a1b9d50fd2"],"access":[]},{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"5f703610-b32b-454e-89c1-73b29950adef","name":"LEAP2","stdName":"LEAP2","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["802d0c22-efd1-4a97-b481-81a1b9d50fd2"],"access":[]},{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"98fcc593-8b49-4bf2-bf47-5691be8806d9","name":"Liver-expressed antimicrobial peptide 2","stdName":"LIVER-EXPRESSED ANTIMICROBIAL PEPTIDE 2","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":true,"references":["802d0c22-efd1-4a97-b481-81a1b9d50fd2"],"access":[]}],"codes":[{"created":1786434701949,"createdBy":"ADMIN","lastEdited":1786434701949,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"21fc5cb4-6462-4448-a3eb-327673d1e199","codeSystem":"UNIPROT","code":"Q969E1","type":"PRIMARY","url":"https://www.uniprot.org/uniprotkb/Q969E1/entry#interaction","_isClassification":false,"references":[],"access":[]},{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"38c49f85-12d1-4792-af2d-2a769bc7715c","codeSystem":"FDA UNII","code":"A4E5SCW9Z5","type":"PRIMARY","_isClassification":false,"references":[],"access":[]}],"modifications":{"created":1786434701949,"createdBy":"ADMIN","lastEdited":1786434701949,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"f1d9f930-dc9e-4102-96f1-48bf9ad88eb1","agentModifications":[],"physicalModifications":[],"structuralModifications":[],"references":[],"access":[]},"notes":[],"properties":[{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"51e45bc2-5dfa-44fa-aef5-6cca8574acff","name":"MOL_WEIGHT:NUMBER(CALCULATED)","type":"amount","propertyType":"CHEMICAL","value":{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"bd0f4612-5e61-4abd-aca5-6e20f03bb69c","type":"ESTIMATED","average":4581.32,"units":"Da","references":[],"access":[]},"defining":false,"parameters":[],"references":[],"access":[]},{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"c966f790-c592-497b-b121-86b13967ccb7","name":"Molecular Formula","propertyType":"CHEMICAL","value":{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"1f5f8667-8bc5-4a27-8a1a-e8f97ad8a4cb","type":"ESTIMATED","nonNumericValue":"C191H320N64O57S5","references":[],"access":[]},"defining":false,"parameters":[],"references":[],"access":[]}],"relationships":[{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0dc1c8b8-0c3f-44a0-9359-6dae58401680","amount":{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"09c5aee8-4919-4275-b509-f21ead4c0599","references":[],"access":[]},"relatedSubstance":{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"f79554b0-c19d-40a8-a653-972684f7d4d6","refPname":"GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1A","refuuid":"744efc6a-d7f3-46fa-9215-2ad603c6b99b","substanceClass":"reference","approvalID":"NUJ1I0OY8D","name":"GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1A","linkingID":"NUJ1I0OY8D","references":[],"access":[]},"originatorUuid":"0dc1c8b8-0c3f-44a0-9359-6dae58401680","type":"TARGET->INHIBITOR","references":["6c61168f-8090-473c-aecb-059dc95c4a40"],"access":[]}],"references":[{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"802d0c22-efd1-4a97-b481-81a1b9d50fd2","citation":"https://www.uniprot.org/uniprotkb/Q969E1/entry","docType":"UNIPROT","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"url":"https://www.uniprot.org/uniprotkb/Q969E1/entry","access":[]},{"created":1786434701950,"createdBy":"ADMIN","lastEdited":1786434701950,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"6c61168f-8090-473c-aecb-059dc95c4a40","citation":"Gupta, Deepali, et al. \"A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes.\" Molecular metabolism 46 (2021): 101128.","docType":"JA","publicDomain":true,"tags":[],"url":"https://www.sciencedirect.com/science/article/pii/S2212877820302027","access":[]}],"approvalID":"A4E5SCW9Z5","tags":[],"protein":{"created":1786434701949,"createdBy":"ADMIN","lastEdited":1786434701949,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"83daf3e2-4e65-4d9b-a601-6000e5b9d593","proteinSubType":"ANTIBACTERIAL PEPTIDE","sequenceOrigin":"HUMAN","sequenceType":"COMPLETE","glycosylation":{"created":1786434701949,"createdBy":"ADMIN","lastEdited":1786434701949,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"1088160f-78f4-4169-98b6-8495eda7369a","NGlycosylationSites":[],"OGlycosylationSites":[],"CGlycosylationSites":[],"references":[],"access":[]},"subunits":[{"created":1786434701949,"createdBy":"ADMIN","lastEdited":1786434701949,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"6899b686-64fb-443f-aefc-9b1462325564","sequence":"MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE","subunitIndex":1,"length":40,"references":[],"access":[]}],"otherLinks":[],"disulfideLinks":[{"sites":[{"subunitIndex":1,"residueIndex":23},{"subunitIndex":1,"residueIndex":33}],"sitesShorthand":"1_23;1_33"},{"sites":[{"subunitIndex":1,"residueIndex":17},{"subunitIndex":1,"residueIndex":28}],"sitesShorthand":"1_17;1_28"}],"references":["802d0c22-efd1-4a97-b481-81a1b9d50fd2"],"access":[]},"_name":"Liver-expressed antimicrobial peptide 2","_approvalIDDisplay":"A4E5SCW9Z5","access":[],"_self":"https://gsrs.ncats.nih.gov/api/v1/substances(a2364b6f-b9b0-4b56-bd2a-9b823f7909ca)?view=full"}