{"created":1786378063862,"createdBy":"ADMIN","lastEdited":1786378063862,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"524748b5-2a42-4b81-822e-35062e471925","definitionType":"PRIMARY","definitionLevel":"COMPLETE","substanceClass":"protein","status":"approved","version":"30","approvedBy":"FDA_SRS","names":[{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"8eeb4b72-63c9-610f-b7ed-9d55dae3b049","name":"Cagrilintide","stdName":"CAGRILINTIDE","type":"of","domains":["drug"],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"3122210d-a0b8-4ff2-84d2-ae481ae171dd","nameOrg":"USAN","references":[],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"36efa7fd-2fa9-4f7a-8d72-e1e719178a8f","nameOrg":"INN","references":[],"access":[]}],"preferred":false,"displayName":true,"references":["9c022421-fe4c-04a3-6c1b-7d59cd4881b0","df72fc47-a459-c584-02bc-f722d66d9dad"],"access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"c8adfda8-5ff4-0bd4-8156-2ad90e611ce3","name":"cagrilintide [INN]","stdName":"CAGRILINTIDE [INN]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["9c022421-fe4c-04a3-6c1b-7d59cd4881b0"],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4936864f-b203-e41b-fec2-ff4d82bfc50e","name":"CAGRILINTIDE [USAN]","stdName":"CAGRILINTIDE [USAN]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["df72fc47-a459-c584-02bc-f722d66d9dad"],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"303fb4cd-cd10-7227-4afa-1f990b7918f1","name":"Cagrilintide [WHO-DD]","stdName":"CAGRILINTIDE [WHO-DD]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["855b19e1-d1dc-2161-5ec5-c785868dc720"],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"9542228d-2889-4c94-a5c4-af65c0f1b7be","name":"CagriSema component Cagrilintide","stdName":"CAGRISEMA COMPONENT CAGRILINTIDE","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["905cf586-bbf5-4e81-a3d2-7544611a1a52"],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"89bacd4c-3e29-fa3f-33e6-dd6796c34fe6","name":"L-Prolinamide, N-(19-carboxy-1-oxononadecyl)-L-γ-glutamyl-L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-arginyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-prolyl-L-isoleucyl-L-leucyl-L-prolyl-L-prolyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-, cyclic (3→8)-disulfide","stdName":"L-PROLINAMIDE, N-(19-CARBOXY-1-OXONONADECYL)-L-.GAMMA.-GLUTAMYL-L-LYSYL-L-CYSTEINYL-L-ASPARAGINYL-L-THREONYL-L-ALANYL-L-THREONYL-L-CYSTEINYL-L-ALANYL-L-THREONYL-L-GLUTAMINYL-L-ARGINYL-L-LEUCYL-L-ALANYL-L-.ALPHA.-GLUTAMYL-L-PHENYLALANYL-L-LEUCYL-L-ARGINYL-L-HISTIDYL-L-SERYL-L-SERYL-L-ASPARAGINYL-L-ASPARAGINYL-L-PHENYLALANYLGLYCYL-L-PROLYL-L-ISOLEUCYL-L-LEUCYL-L-PROLYL-L-PROLYL-L-THREONYL-L-ASPARAGINYL-L-VALYLGLYCYL-L-SERYL-L-ASPARAGINYL-L-THREONYL-, CYCLIC (3->8)-DISULFIDE","type":"sys","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["e4255bf4-5d67-eff5-7a52-0cd7e17e68dc","df72fc47-a459-c584-02bc-f722d66d9dad"],"access":[]}],"codes":[{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"58dd10ac-6937-441a-8c2c-a331164f7379","codeSystem":"CAS","code":"1415456-99-3","type":"PRIMARY","url":"https://commonchemistry.cas.org/detail?cas_rn=1415456-99-3","_isClassification":false,"references":["e4255bf4-5d67-eff5-7a52-0cd7e17e68dc"],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"69801119-d0a8-ed0e-efae-43430558ea34","codeSystem":"INN","code":"11430","type":"PRIMARY","url":"https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=11430","_isClassification":false,"references":["9c022421-fe4c-04a3-6c1b-7d59cd4881b0"],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"6c7bcb0b-0f97-4d23-e95a-2a6ce9c79dff","codeSystem":"USAN","code":"LM-28","type":"PRIMARY","url":"https://searchusan.ama-assn.org/finder/usan/search/LM-28/relevant/1/","_isClassification":false,"references":["df72fc47-a459-c584-02bc-f722d66d9dad"],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b4ad5140-e48a-d6bc-3155-4c57b3172bdf","codeSystem":"NCI_THESAURUS","code":"C175752","type":"PRIMARY","url":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C175752","_isClassification":false,"references":["5d1d7d9e-989a-0dbe-0a41-bfb1c4c913d0"],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"e486ea93-2d04-4279-a720-0b1965740dd6","codeSystem":"FDA UNII","code":"AO43BIF1U8","type":"PRIMARY","_isClassification":false,"references":[],"access":[]},{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"f35e0931-e177-7cb0-e92a-e9a04051ca2d","codeSystem":"SMS_ID","code":"300000031432","type":"PRIMARY","_isClassification":false,"references":["f071e338-9f3f-382c-7f3f-55bcdfe1e4b8"],"access":[]}],"modifications":{"created":1786378063874,"createdBy":"ADMIN","lastEdited":1786378063874,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"d381eeb5-8b1d-44d7-af9a-8c1020787fff","agentModifications":[],"physicalModifications":[],"structuralModifications":[{"created":1786378063874,"createdBy":"ADMIN","lastEdited":1786378063874,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"79fa5bfa-fd41-4342-b528-3c7d7101c9ca","structuralModificationType":"AMINO ACID SUBSTITUTION","locationType":"N-TERMINUS","residueModified":"Lys","extent":"COMPLETE","molecularFragment":{"created":1786378063874,"createdBy":"ADMIN","lastEdited":1786378063874,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"bab3e131-4449-4a79-8f8d-071293f2b844","refPname":"N-(19-carboxy-1-oxononadecyl)-L-γ-glutamyl-L-lysine","refuuid":"5fd6128d-82c3-4349-adc2-73ed6d81865b","substanceClass":"reference","approvalID":"XKP2SC88E6","name":"N-(19-carboxy-1-oxononadecyl)-L-γ-glutamyl-L-lysine","linkingID":"XKP2SC88E6","references":[],"access":[]},"modificationGroup":"1","sites":[{"subunitIndex":1,"residueIndex":1}],"references":[],"access":[]},{"created":1786378063874,"createdBy":"ADMIN","lastEdited":1786378063874,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"9e258cc7-fef6-489f-9066-f7e6dc0dd29b","structuralModificationType":"AMINO ACID SUBSTITUTION","locationType":"C-TERMINUS","residueModified":"Pro","extent":"COMPLETE","molecularFragment":{"created":1786378063874,"createdBy":"ADMIN","lastEdited":1786378063874,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"66b3942f-97bf-4984-be8f-2eabccff69a7","refPname":"PROLINAMIDE","refuuid":"c1d759bc-946a-47d4-9e5b-3ad6a542401c","substanceClass":"reference","approvalID":"VD6PQK9DHG","name":"PROLINAMIDE","linkingID":"VD6PQK9DHG","references":[],"access":[]},"modificationGroup":"1","sites":[{"subunitIndex":1,"residueIndex":37}],"references":[],"access":[]}],"references":[],"access":[]},"notes":[{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063878,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"58cbd95d-c554-41fe-aa57-6123584926c6","note":"[Validation]WARNING:Structural modification will not affect the molecular weight because N-(19-carboxy-1-oxononadecyl)-L-γ-glutamyl-L-lysine has no associated molecular weight","references":["8a631df6-476e-4fb3-80e0-8cb79c091947"],"access":["admin"]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063878,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"869bfe30-da32-42c7-a79a-9c4c89e7f780","note":"[Validation]WARNING:Calculated weight [3955.44] is greater than 1.00% off of given weight [4409.00]","references":["8a631df6-476e-4fb3-80e0-8cb79c091947"],"access":["admin"]}],"properties":[{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"31722457-6868-48bc-bf50-f56262d80a91","name":"Molecular Formula","propertyType":"CHEMICAL","value":{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b528b798-9615-49e3-9bfc-20323b804809","type":"ESTIMATED","nonNumericValue":"C194H312O58N54S2","references":[],"access":[]},"defining":false,"parameters":[],"references":[],"access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"e5254e7e-6c0f-4776-b837-5dd9b745d0c1","name":"MOL_WEIGHT:NUMBER(CALCULATED)","type":"amount","propertyType":"CHEMICAL","value":{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"45305497-f92f-487e-9c1a-4703e6989820","type":"EXACT","average":4409.0,"units":"Da","references":[],"access":[]},"defining":false,"parameters":[],"references":[],"access":[]}],"relationships":[{"created":1786378063877,"createdBy":"ADMIN","lastEdited":1786378063877,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"087322a0-ef98-403b-94f9-7001e8f78aa0","amount":{"created":1786378063877,"createdBy":"ADMIN","lastEdited":1786378063877,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4397ccad-480f-4b6c-884e-056edf857812","references":[],"access":[]},"relatedSubstance":{"created":1786378063877,"createdBy":"ADMIN","lastEdited":1786378063877,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"8edc2ee0-9501-4b57-bafc-45876d6c3c9b","refPname":"Cagrilintide hydrochloride","refuuid":"19ead88d-bc78-4912-af60-33dbe3cf6ed0","substanceClass":"reference","approvalID":"3SBY6D7WH7","name":"Cagrilintide hydrochloride","linkingID":"3SBY6D7WH7","references":[],"access":[]},"originatorUuid":"a157b525-7c52-fb19-dc6f-99493f56c42f","type":"SALT/SOLVATE->PARENT","references":["d8e35943-749a-4e42-b00d-2db5b72d770d"],"access":[]},{"created":1786378063877,"createdBy":"ADMIN","lastEdited":1786378063877,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"5a73b4a3-13e5-4051-b065-0c886d04a4a4","amount":{"created":1786378063877,"createdBy":"ADMIN","lastEdited":1786378063877,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4a66bd5a-ea9c-4b1d-bac3-d3ae150554b9","references":[],"access":[]},"relatedSubstance":{"created":1786378063877,"createdBy":"ADMIN","lastEdited":1786378063877,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"2d4bc58e-7408-4b78-ae62-c3a1b03233ef","refPname":"Cagrilintide","refuuid":"524748b5-2a42-4b81-822e-35062e471925","substanceClass":"reference","approvalID":"AO43BIF1U8","name":"Cagrilintide","linkingID":"AO43BIF1U8","references":[],"access":[]},"originatorUuid":"5a73b4a3-13e5-4051-b065-0c886d04a4a4","type":"ACTIVE MOIETY","references":[],"access":[]},{"created":1786378063877,"createdBy":"ADMIN","lastEdited":1786378063877,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"7b149193-7e8e-4ae9-beda-cf08868a6162","amount":{"created":1786378063877,"createdBy":"ADMIN","lastEdited":1786378063877,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"bb0b131c-c119-40b0-8e59-adf3cc3fcdd0","references":[],"access":[]},"relatedSubstance":{"created":1786378063877,"createdBy":"ADMIN","lastEdited":1786378063877,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"c27289f4-6e90-4d38-90c1-dfc09fb41848","refPname":"AMLINTIDE","refuuid":"b65babbb-0acd-4d11-8dd2-a72e56738af1","substanceClass":"reference","approvalID":"U3U3114NE1","name":"AMLINTIDE","linkingID":"U3U3114NE1","references":[],"access":[]},"originatorUuid":"7b149193-7e8e-4ae9-beda-cf08868a6162","type":"TARGET->MIMETIC","references":["0b78efff-4035-4a70-ad81-f57431b34a04"],"access":[]}],"references":[{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0b78efff-4035-4a70-ad81-f57431b34a04","citation":"https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01751-7/fulltext","docType":"WEBSITE","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"url":"https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01751-7/fulltext","access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"5d1d7d9e-989a-0dbe-0a41-bfb1c4c913d0","citation":"NCI","docType":"NCI THESAURUS","publicDomain":true,"tags":[],"access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"855b19e1-d1dc-2161-5ec5-c785868dc720","citation":"WHO-DD","docType":"WHO DRUG DICTIONARY","publicDomain":true,"tags":[],"access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"8a631df6-476e-4fb3-80e0-8cb79c091947","citation":"GSRS System-generated Validation messages","docType":"VALIDATION_MESSAGE","documentDate":1786378063860,"publicDomain":false,"tags":[],"access":["admin"]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"905cf586-bbf5-4e81-a3d2-7544611a1a52","citation":"https://diatribe.org/semaglutide-tirzepatide-cagrisema-oh-my-emerging-treatment-options-obesity-and-type-2-diabetes","docType":"WEB PAGE","publicDomain":true,"tags":[],"url":"https://diatribe.org/semaglutide-tirzepatide-cagrisema-oh-my-emerging-treatment-options-obesity-and-type-2-diabetes","access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"90db867f-42fb-4d02-a257-83c4b30b6771","citation":"SRS","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"9c022421-fe4c-04a3-6c1b-7d59cd4881b0","citation":"INN Proposed List 123","docType":"INN_LIST","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"url":"https://www.who.int/medicines/publications/druginformation/innlists/PL123.pdf","access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"d8e35943-749a-4e42-b00d-2db5b72d770d","citation":"STN","docType":"STN (SCIFINDER)","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE","NOMEN"],"access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"df72fc47-a459-c584-02bc-f722d66d9dad","citation":"USAN COUN 2023","docType":"USANCOUN","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"uploadedFile":"https://gsrs.fda.gov/api/v1/payload(b8a7773e-1ddc-4fa3-9840-d1c9ffcdfd0b)?format=raw","access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"e4255bf4-5d67-eff5-7a52-0cd7e17e68dc","citation":"STN","docType":"STN (SCIFINDER)","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE","NOMEN"],"access":[]},{"created":1786378063876,"createdBy":"ADMIN","lastEdited":1786378063876,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"f071e338-9f3f-382c-7f3f-55bcdfe1e4b8","citation":"SMS","docType":"EMA LIST","publicDomain":true,"tags":[],"access":[]}],"approvalID":"AO43BIF1U8","tags":[],"protein":{"created":1786378063874,"createdBy":"ADMIN","lastEdited":1786453985869,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b2c4a3c8-5254-4da0-b196-a4b0722f6332","proteinType":"PEPTIDE","proteinSubType":"AMYLIN ANALOG","sequenceOrigin":"HUMAN","sequenceType":"COMPLETE","glycosylation":{"created":1786378063874,"createdBy":"ADMIN","lastEdited":1786378063874,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"f44d47e2-ff57-4773-9bb3-aeb92fec2ff9","NGlycosylationSites":[],"OGlycosylationSites":[],"CGlycosylationSites":[],"references":[],"access":[]},"subunits":[{"created":1786378063875,"createdBy":"ADMIN","lastEdited":1786378063875,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"ab6d0c29-fc55-4362-b646-32376e73cbec","sequence":"KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP","subunitIndex":1,"length":37,"references":[],"access":[]}],"otherLinks":[],"disulfideLinks":[{"sites":[{"subunitIndex":1,"residueIndex":2},{"subunitIndex":1,"residueIndex":7}],"sitesShorthand":"1_2;1_7"}],"references":["90db867f-42fb-4d02-a257-83c4b30b6771","e4255bf4-5d67-eff5-7a52-0cd7e17e68dc","9c022421-fe4c-04a3-6c1b-7d59cd4881b0"],"access":[]},"_name":"Cagrilintide","_approvalIDDisplay":"AO43BIF1U8","access":[],"_self":"https://gsrs.ncats.nih.gov/api/v1/substances(524748b5-2a42-4b81-822e-35062e471925)?view=full"}