{"created":1786440824295,"createdBy":"ADMIN","lastEdited":1786440824295,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"16a3738b-e63b-ea92-8d33-77fab5605eda","definitionType":"PRIMARY","definitionLevel":"COMPLETE","substanceClass":"protein","status":"approved","version":"25","approvedBy":"FDA_SRS","names":[{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b3ea7134-4ebf-9766-3422-36aa86b4bff7","name":"BI-456906","stdName":"BI-456906","type":"cd","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["9c53cc08-1e3a-478f-bc3f-a361aabdd876"],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"1286a997-bf4b-706b-d106-0ad62c4f6a8c","name":"BI456906","stdName":"BI456906","type":"cd","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["9c53cc08-1e3a-478f-bc3f-a361aabdd876"],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"2c330d1f-6bba-484d-bc0d-f2454652dfa1","name":"L-Alaninamide, L-histidyl-1-aminocyclobutanecarbonyl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-α-glutamyl-L-arginyl-L-alanyl-L-alanyl-L-lysyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamylglycyl-L-serylglycyl-L-serylglycylglycyl]-L-lysyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-seryl-","stdName":"L-ALANINAMIDE, L-HISTIDYL-1-AMINOCYCLOBUTANECARBONYL-L-GLUTAMINYLGLYCYL-L-THREONYL-L-PHENYLALANYL-L-THREONYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-TYROSYL-L-SERYL-L-LYSYL-L-TYROSYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-ALANYL-L-ALANYL-L-LYSYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANYL-L-ISOLEUCYL-N6-(N-(17-CARBOXY-1-OXOHEPTADECYL)-L-.GAMMA.-GLUTAMYLGLYCYL-L-SERYLGLYCYL-L-SERYLGLYCYLGLYCYL)-L-LYSYL-L-TRYPTOPHYL-L-LEUCYL-L-.ALPHA.-GLUTAMYL-L-SERYL-","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["3da10157-d8da-446a-b2ec-c70d1fc99f63","a21d1632-b5e2-4168-b62a-9e0e9e3c7192"],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"e91d5eac-0cf7-4db1-abf1-8f8ed3795a61","name":"L-Histidyl-1-aminocyclobutanecarbonyl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-α-glutamyl-L-arginyl-L-alanyl-L-alanyl-L-lysyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamylglycyl-L-serylglycyl-L-serylglycylglycyl]-L-lysyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-seryl-L-alaninamide","stdName":"L-HISTIDYL-1-AMINOCYCLOBUTANECARBONYL-L-GLUTAMINYLGLYCYL-L-THREONYL-L-PHENYLALANYL-L-THREONYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-TYROSYL-L-SERYL-L-LYSYL-L-TYROSYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-ALANYL-L-ALANYL-L-LYSYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANYL-L-ISOLEUCYL-N6-(N-(17-CARBOXY-1-OXOHEPTADECYL)-L-.GAMMA.-GLUTAMYLGLYCYL-L-SERYLGLYCYL-L-SERYLGLYCYLGLYCYL)-L-LYSYL-L-TRYPTOPHYL-L-LEUCYL-L-.ALPHA.-GLUTAMYL-L-SERYL-L-ALANINAMIDE","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["a21d1632-b5e2-4168-b62a-9e0e9e3c7192"],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"28ec10a2-4004-4443-88ec-0ddfc3bc5b84","name":"SURVODUTIDE [USAN]","stdName":"SURVODUTIDE [USAN]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["9c53cc08-1e3a-478f-bc3f-a361aabdd876"],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"5c8f0ae1-de73-4e81-86b7-523c1e0eb967","name":"Survodutide","stdName":"SURVODUTIDE","type":"of","domains":["drug"],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b03436fa-b1b2-40a3-b2b2-6161e2d1c96f","nameOrg":"USAN","references":[],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"63e3a3fe-3de8-4234-9750-183fd6d861bd","nameOrg":"INN","references":[],"access":[]}],"preferred":false,"displayName":true,"references":["3da10157-d8da-446a-b2ec-c70d1fc99f63"],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"46a3335f-b868-2bbd-b899-3faa0da772ba","name":"Survodutide [WHO-DD]","stdName":"SURVODUTIDE [WHO-DD]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["bac04484-e1f3-9051-2d1e-0ecf7c712f0e"],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0277a0cb-6bcc-4d9e-9b8c-6291ddf93552","name":"survodutide [INN]","stdName":"SURVODUTIDE [INN]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["3da10157-d8da-446a-b2ec-c70d1fc99f63"],"access":[]}],"codes":[{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"310da6fc-1462-0b9b-7a08-3d65407d44aa","codeSystem":"SMS_ID","code":"300000026812","type":"PRIMARY","_isClassification":false,"references":["67cb0c94-5e45-8646-078d-e61e03ac1cf5"],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"521b95c9-6cbb-430f-909a-9a7234476bff","codeSystem":"NCI_THESAURUS","code":"C199114","type":"PRIMARY","url":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C199114","_isClassification":false,"references":["b3e7bace-a5ef-4b75-a72e-0dad90102423"],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"5fd5deac-772f-49d6-ba98-2f8b6c7060cf","codeSystem":"USAN","code":"MN-45","type":"PRIMARY","url":"https://searchusan.ama-assn.org/finder/usan/search/MN-45/relevant/1/","_isClassification":false,"references":[],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"67d30be4-4762-43c2-b411-732dd3377419","codeSystem":"INN","code":"12491","type":"PRIMARY","url":"https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=12491","_isClassification":false,"references":["3da10157-d8da-446a-b2ec-c70d1fc99f63"],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":true,"uuid":"b4be8cad-b24a-444d-ad6a-2461901214b8","codeSystem":"FDA UNII","code":"2ALA66NS64","type":"PRIMARY","_isClassification":false,"references":[],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"229d8ecd-d8fb-4ca2-8aa3-4f4a8e8f1637","codeSystem":"CAS","code":"2805997-46-8","type":"PRIMARY","url":"https://commonchemistry.cas.org/detail?cas_rn=2805997-46-8","_isClassification":false,"references":["9c53cc08-1e3a-478f-bc3f-a361aabdd876"],"access":[]}],"modifications":{"created":1786440824309,"createdBy":"ADMIN","lastEdited":1786440824309,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"3eba50c2-85b9-4263-bf70-4557a5312183","agentModifications":[],"physicalModifications":[],"structuralModifications":[{"created":1786440824309,"createdBy":"ADMIN","lastEdited":1786440824309,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0eeb5dff-7b80-44bc-a031-4555b471179b","structuralModificationType":"AMINO_ACID_SUBSTITUTION","locationType":"SITE_SPECIFIC","residueModified":"G","extent":"COMPLETE","molecularFragment":{"created":1786440824309,"createdBy":"ADMIN","lastEdited":1786440824309,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"1e877edb-1437-439c-bcc1-5b8c81318081","refPname":"N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamylglycine","refuuid":"fa188099-4430-4fc5-b75c-7e9d1bf84fce","substanceClass":"reference","approvalID":"ADS5D64S87","name":"N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamylglycine","linkingID":"ADS5D64S87","references":[],"access":[]},"modificationGroup":"1","sites":[{"subunitIndex":2,"residueIndex":1}],"references":[],"access":[]}],"references":[],"access":[]},"notes":[{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824312,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"fdccc4fd-0186-40b2-8e28-b32c218c8743","note":"[Validation]WARNING:Protein has unknown amino acid residues: [X]","references":["f6222e58-b025-4c15-8698-f78e3b804b97"],"access":["admin"]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824312,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b118294c-f2e8-40bf-b5e6-396d46e244d9","note":"[Validation]WARNING:Structural modification will not affect the molecular weight because N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamylglycine has no associated molecular weight","references":["f6222e58-b025-4c15-8698-f78e3b804b97"],"access":["admin"]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824312,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"a6ba05e3-0937-4ed2-be74-1ef700ac7e2d","note":"[Validation]WARNING:Calculated weight [3728.01] is greater than 1.00% off of given weight [3300.00]","references":["f6222e58-b025-4c15-8698-f78e3b804b97"],"access":["admin"]}],"properties":[{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"520c4185-d5cf-4ab3-879d-b1f9d28b8c50","name":"MOL_WEIGHT:NUMBER(CALCULATED)","type":"amount","propertyType":"CHEMICAL","value":{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"c1a2b3e7-b268-4804-80aa-ef3e6e1e1cd0","type":"ESTIMATED","average":3300.0,"units":"Da","references":[],"access":[]},"defining":false,"parameters":[],"references":[],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"2ae824a4-0a54-4b66-97ad-6ca15cbaccb0","name":"Molecular Formula","propertyType":"CHEMICAL","value":{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"7ed392dd-3355-4aec-94c3-9e7d0d40b117","type":"ESTIMATED","nonNumericValue":"C192H289N47O61","references":[],"access":[]},"defining":false,"parameters":[],"references":[],"access":[]}],"relationships":[{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"a16926af-f7fc-4343-86d2-ac2039667cc3","amount":{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"46dd37e2-4224-4204-82c2-994f6b0ce998","references":[],"access":[]},"relatedSubstance":{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"5ce77002-67cc-4bb0-9671-1a6f14d0ecdc","refPname":"OXYNTOMODULIN HUMAN","refuuid":"130cd2d6-8b12-4690-a6c4-2fdf869d2b2b","substanceClass":"reference","approvalID":"LV7ELH7V16","name":"OXYNTOMODULIN HUMAN","linkingID":"LV7ELH7V16","references":[],"access":[]},"originatorUuid":"a16926af-f7fc-4343-86d2-ac2039667cc3","type":"TARGET->MIMETIC","references":["0811e97f-ecea-4763-840e-8faae2ca5dbd"],"access":[]},{"created":1786440824312,"createdBy":"ADMIN","lastEdited":1786440824312,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"7bb74fe3-f104-4ece-8af5-4f9e117ac11b","amount":{"created":1786440824312,"createdBy":"ADMIN","lastEdited":1786440824312,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"1b4ee721-12db-4c98-8dbd-b446864d41a3","references":[],"access":[]},"relatedSubstance":{"created":1786440824312,"createdBy":"ADMIN","lastEdited":1786440824312,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"3373df9a-75f8-43ad-904e-ccaec35c4217","refPname":"Survodutide","refuuid":"16a3738b-e63b-ea92-8d33-77fab5605eda","substanceClass":"reference","approvalID":"2ALA66NS64","name":"Survodutide","linkingID":"2ALA66NS64","references":[],"access":[]},"originatorUuid":"7bb74fe3-f104-4ece-8af5-4f9e117ac11b","type":"ACTIVE MOIETY","references":[],"access":[]}],"references":[{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0811e97f-ecea-4763-840e-8faae2ca5dbd","citation":"FDA_SRS","docType":"FDA_SRS","publicDomain":true,"tags":[],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"a21d1632-b5e2-4168-b62a-9e0e9e3c7192","citation":"STN","docType":"STN (SCIFINDER)","publicDomain":true,"tags":[],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"3da10157-d8da-446a-b2ec-c70d1fc99f63","citation":"SURVODUTIDE","docType":"INN","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"url":"https://extranet.who.int/tools/inn_global_data_hub/INN_Hub.php?code=pOPhnr3gR7J9JgvyUdvwn48vCxkwQlYzwOglPUegyBpspz0qA65JTwZ4OF4qrGxc","access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b3e7bace-a5ef-4b75-a72e-0dad90102423","citation":"NCIT","docType":"NCI THESAURUS","publicDomain":true,"tags":[],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"9c53cc08-1e3a-478f-bc3f-a361aabdd876","citation":"USAN COUN 2024","docType":"USANCOUN","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"uploadedFile":"https://gsrs.fda.gov/api/v1/payload(7744a93f-83d8-4fea-8bf7-2a895d08c46e)?format=raw","access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"8e9a4c37-e400-5406-6e52-9fd7e45be845","citation":"FDA_SRS","docType":"FDA_SRS","publicDomain":true,"tags":[],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"a62a324a-5d11-99fe-19a2-297ca58eb332","citation":"STN","docType":"STN (SCIFINDER)","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"6a918ad7-929c-153c-c133-54e23c2c07bb","citation":"INN List 128","docType":"INN_LIST","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"url":"https://extranet.who.int/tools/inn_global_data_hub/INN_Hub.php?code=pOPhnr3gR7J9JgvyUdvwn48vCxkwQlYzwOglPUegyBpspz0qA65JTwZ4OF4qrGxc","access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"67cb0c94-5e45-8646-078d-e61e03ac1cf5","citation":"SMS","docType":"EMA LIST","publicDomain":true,"tags":[],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"bac04484-e1f3-9051-2d1e-0ecf7c712f0e","citation":"WHO-DD","docType":"WHO DRUG DICTIONARY","publicDomain":true,"tags":[],"access":[]},{"created":1786440824311,"createdBy":"ADMIN","lastEdited":1786440824311,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"f6222e58-b025-4c15-8698-f78e3b804b97","citation":"GSRS System-generated Validation messages","docType":"VALIDATION_MESSAGE","documentDate":1786440824293,"publicDomain":false,"tags":[],"access":["admin"]}],"approvalID":"2ALA66NS64","tags":[],"protein":{"created":1786440824309,"createdBy":"ADMIN","lastEdited":1786440824309,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"68cd8514-a01f-46e8-aaa7-4159bd16b166","proteinType":"PEPTIDE","proteinSubType":"HORMONE","sequenceOrigin":"SYNTHETIC","sequenceType":"COMPLETE","glycosylation":{"created":1786440824309,"createdBy":"ADMIN","lastEdited":1786440824309,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b28eb8ad-35c2-42bf-ba5d-06e986c33d41","NGlycosylationSites":[],"OGlycosylationSites":[],"CGlycosylationSites":[],"references":[],"access":[]},"subunits":[{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"53000326-9f8f-4c0f-be89-9c48bbe97362","sequence":"HXQGTFTSDYSKYLDERAAKDFIKWLESA","subunitIndex":1,"length":29,"references":[],"access":[]},{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"a2c7bc02-4886-45c0-ae1e-80c186e81305","sequence":"GSGSGG","subunitIndex":2,"length":6,"references":[],"access":[]}],"otherLinks":[{"created":1786440824310,"createdBy":"ADMIN","lastEdited":1786440824310,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"7ca52922-6411-4072-896d-b723b7a3178d","linkageType":"AMIDE BOND","sites":[{"subunitIndex":1,"residueIndex":24},{"subunitIndex":2,"residueIndex":6}],"references":[],"access":[]}],"disulfideLinks":[],"references":["9c53cc08-1e3a-478f-bc3f-a361aabdd876","3da10157-d8da-446a-b2ec-c70d1fc99f63"],"access":[]},"_name":"Survodutide","_approvalIDDisplay":"2ALA66NS64","access":[],"_self":"https://gsrs.ncats.nih.gov/api/v1/substances(16a3738b-e63b-ea92-8d33-77fab5605eda)?view=full"}