{"created":1786331470191,"createdBy":"ADMIN","lastEdited":1786331470191,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"21a0f610-ab27-4d76-afca-610b7abc040c","definitionType":"PRIMARY","definitionLevel":"COMPLETE","substanceClass":"chemical","status":"approved","version":"50","approvedBy":"FDA_SRS","names":[{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"3b302618-011b-46a8-bb11-edded12532f5","name":"(1RS,1'RS)-1,1'-((2RS,2'SR)-BIS(6-FLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-YL))-2,2'-IMINODIETHANOL HYDROCHLORIDE","stdName":"(1RS,1'RS)-1,1'-((2RS,2'SR)-BIS(6-FLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-YL))-2,2'-IMINODIETHANOL HYDROCHLORIDE","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["b0c1fff4-bbc8-4972-9b6d-8f2378f8219e"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4da339e1-808d-495a-adc3-9ad9341337e8","name":"(RS)-1-[(RS)-6-Fluorochroman-2-yl]-2-({(RS)-2-[(SR)-6-fluorochroman-2-yl]-2-hydroxyethyl}amino)ethan-1-ol hydrochloride","stdName":"(RS)-1-((RS)-6-FLUOROCHROMAN-2-YL)-2-(((RS)-2-((SR)-6-FLUOROCHROMAN-2-YL)-2-HYDROXYETHYL)AMINO)ETHAN-1-OL HYDROCHLORIDE","type":"sys","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["b0c1fff4-bbc8-4972-9b6d-8f2378f8219e","18bc912e-1838-4870-ab5b-40fa54bb59bf"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0558fe42-6048-4043-9fb1-34080ddad466","name":"2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-","stdName":"2H-1-BENZOPYRAN-2-METHANOL, .ALPHA.,.ALPHA.'-(IMINOBIS(METHYLENE))BIS(6-FLUORO-3,4-DIHYDRO-, HYDROCHLORIDE (1:1), (.ALPHA.R,.ALPHA.'R,2R,2'S)-REL-","type":"sys","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["18bc912e-1838-4870-ab5b-40fa54bb59bf"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"10164e19-3f45-42dd-b82e-6143dbec3dca","name":"BYSTOLIC","stdName":"BYSTOLIC","type":"bn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["c5873edd-11f5-4cd5-91b9-9a5390968a92"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"1a5e6410-e6fb-47b5-a9a8-6175dc4ea24b","name":"BYVALSON COMPONENT NEBIVOLOL HYDROCHLORIDE","stdName":"BYVALSON COMPONENT NEBIVOLOL HYDROCHLORIDE","type":"bn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["886b02ad-450d-4a18-904d-82191ea2cb77"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"e1d230f6-0f68-451d-8fbb-ccdebeaf3eb7","name":"NEBIVOLOL HCL","stdName":"NEBIVOLOL HCL","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["ec8341f2-01bf-46da-91f8-dda24a52141c"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"323e1737-7db3-432d-abfe-13abcb57e3c1","name":"Nebivolol hydrochloride","stdName":"NEBIVOLOL HYDROCHLORIDE","type":"of","domains":["drug"],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"9e8d2b80-0760-4b93-99f2-d5d5e1c6a7ff","nameOrg":"USAN","references":[],"access":[]}],"preferred":false,"displayName":true,"references":["386e8ce0-56cf-444f-9545-368a673bb262","b06d3d47-bbe2-4669-b367-be72323662a5","1fcf8df3-2442-4e8f-867a-029f4d6b23b7","acc51950-fc30-4837-bd8a-9f30720c99ab","8c605a24-be38-41cc-803e-e8e9ff8b3b30","0980b947-a3c6-4cfb-856e-d05fa6e8af8b","58e95db9-f575-4238-aff2-f923f5725c6a","48f2f16b-9aa7-4abb-a7ea-7ea9efe32460","cdd94218-9f53-4d1d-b658-6c547595577b","86f5371c-220c-4fa3-986b-745cfcc2f5f9","d0b43f17-5db0-4a65-bc5d-078e2b62fbe7"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4d209805-2d81-49cb-b93a-e173424f9ba7","name":"Nebivolol hydrochloride [EP MONOGRAPH]","stdName":"NEBIVOLOL HYDROCHLORIDE [EP MONOGRAPH]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["4423e931-6b20-4150-8226-d71eedc2ed19"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"45e00dc2-2ad0-4315-854d-614825fe844b","name":"NEBIVOLOL HYDROCHLORIDE [MART.]","stdName":"NEBIVOLOL HYDROCHLORIDE [MART.]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["b06d3d47-bbe2-4669-b367-be72323662a5"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"eb5d6937-6f54-4d80-88b5-8399c62f199d","name":"NEBIVOLOL HYDROCHLORIDE [MI]","stdName":"NEBIVOLOL HYDROCHLORIDE [MI]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["58e95db9-f575-4238-aff2-f923f5725c6a"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"459e5941-f19d-4f00-b115-31f6742710c6","name":"NEBIVOLOL HYDROCHLORIDE [ORANGE BOOK]","stdName":"NEBIVOLOL HYDROCHLORIDE [ORANGE BOOK]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["48f2f16b-9aa7-4abb-a7ea-7ea9efe32460"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"c8804973-73f2-4dc6-bfa3-e3f9adb478c8","name":"NEBIVOLOL HYDROCHLORIDE [USAN]","stdName":"NEBIVOLOL HYDROCHLORIDE [USAN]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["386e8ce0-56cf-444f-9545-368a673bb262"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"334ff8b1-f539-dfda-9ede-03789ac8f134","name":"NEBIVOLOL HYDROCHLORIDE [USP-RS]","stdName":"NEBIVOLOL HYDROCHLORIDE [USP-RS]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["c63df0a6-ac47-9f9f-3425-654a94d15aa4"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"65684996-2ea3-ffab-6595-e9688d5bd922","name":"Nebivolol hydrochloride [WHO-DD]","stdName":"NEBIVOLOL HYDROCHLORIDE [WHO-DD]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["57370dfb-50f1-d378-7dbd-c118b96d1450"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"c5dc4a0b-5332-4cba-bafc-ff23083e9dc0","name":"R-067555","stdName":"R-067555","type":"cd","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["660c4ee5-b753-47ee-8368-ff82401e91c4"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"474d4e2c-a124-4196-8c13-8f5277ecb95c","name":"R067555","stdName":"R067555","type":"cd","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["b0c1fff4-bbc8-4972-9b6d-8f2378f8219e"],"access":[]}],"codes":[{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"1da78a09-4530-4a7a-9c28-5ac1d18694c3","codeSystem":"FDA UNII","code":"JGS34J7L9I","type":"PRIMARY","_isClassification":false,"references":[],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4085c1b3-ba2e-788c-373c-a5edb1fda08f","codeSystem":"USAN","code":"QQ-75","type":"PRIMARY","url":"https://searchusan.ama-assn.org/finder/usan/search/QQ-75/relevant/1/","_isClassification":false,"references":["74f49e0c-d0b1-99e5-6fd8-fcc627c44c49"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4956f658-e94b-4bed-9ead-965f10c67dbb","codeSystem":"MERCK INDEX","code":"m7786","comments":"Merck Index","type":"PRIMARY","url":"https://merckindex.rsc.org/monographs/m7786?q=authorize","_isClassification":false,"references":["0caf62c3-c444-4e01-8451-dae62c68ad7b"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"56e31d7e-a908-49c6-8960-f8bb4db90fc8","codeSystem":"NCI_THESAURUS","code":"C81656","type":"PRIMARY","url":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C81656","_isClassification":false,"references":["0caf62c3-c444-4e01-8451-dae62c68ad7b"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"65598523-b04f-965c-8103-8feea6097064","codeSystem":"RS_ITEM_NUM","code":"1457833","type":"PRIMARY","url":"https://store.usp.org/product/1457833","_isClassification":false,"references":["4c696a42-7237-00e5-173b-0e172a48d68b"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"718880dc-4872-7753-835f-b51b0e4aa3f2","codeSystem":"SMS_ID","code":"100000093063","type":"PRIMARY","_isClassification":false,"references":["724d6646-1c64-997e-6ba6-8b5f0113d758"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"8f8b63b8-ce8b-4886-988d-7203e4ecb1c1","codeSystem":"EVMPD","code":"SUB14632MIG","type":"PRIMARY","_isClassification":false,"references":["0caf62c3-c444-4e01-8451-dae62c68ad7b"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"a4af0844-1e0f-d06d-b6ce-e8f2f43496d4","codeSystem":"DRUG BANK","code":"DBSALT001027","type":"PRIMARY","url":"https://go.drugbank.com/drugs/DBSALT001027","_isClassification":false,"references":["4c696a42-7237-00e5-173b-0e172a48d68b"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"afef2705-d10d-c9bb-f8a2-18883c1f2e2c","codeSystem":"PUBCHEM","code":"11812257","type":"PRIMARY","url":"https://pubchem.ncbi.nlm.nih.gov/compound/11812257","_isClassification":false,"references":["d2e447a7-95bf-a128-748a-e74f6c4ef789"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b28540f1-7829-466f-9c29-c10392e03453","codeSystem":"RXCUI","code":"236883","comments":"RxNorm","type":"PRIMARY","url":"https://rxnav.nlm.nih.gov/REST/rxcui/236883/allProperties.xml?prop=all","_isClassification":false,"references":["0caf62c3-c444-4e01-8451-dae62c68ad7b"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"cb20ba31-9f0d-a00e-077e-7f343faacb2b","codeSystem":"DAILYMED","code":"JGS34J7L9I","type":"PRIMARY","url":"https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=JGS34J7L9I","_isClassification":false,"references":["32ac6360-04a6-57bf-c3e9-e1d67fd9b667"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"d532314d-8d78-49bc-9dab-9d3c8b8fd152","codeSystem":"CAS","code":"152520-56-4","type":"PRIMARY","url":"https://commonchemistry.cas.org/detail?cas_rn=152520-56-4","_isClassification":false,"references":["0caf62c3-c444-4e01-8451-dae62c68ad7b","18bc912e-1838-4870-ab5b-40fa54bb59bf"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"de2375d1-31d2-5652-8520-9e525fadeae8","codeSystem":"NCI_THESAURUS","code":"C29576","comments":"Pharmacologic Substance[C1909]|Agent Affecting Nervous System[C78272]|Adrenergic Agent[C29747]|Adrenergic Antagonist[C72900]|Beta-Adrenergic Antagonist","type":"CONCEPT","url":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C29576","_isClassification":true,"references":["4c696a42-7237-00e5-173b-0e172a48d68b"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"ecc2747d-733b-4f05-bde7-22539286a6ff","codeSystem":"ChEMBL","code":"CHEMBL434394","type":"PRIMARY","url":"https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL434394","_isClassification":false,"references":["0caf62c3-c444-4e01-8451-dae62c68ad7b"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"f88979a1-66dd-d4d4-2d6a-1d331821f6dd","codeSystem":"CHEBI","code":"132912","type":"PRIMARY","url":"https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:132912","_isClassification":false,"references":["4c696a42-7237-00e5-173b-0e172a48d68b"],"access":[]},{"created":1786331470203,"createdBy":"ADMIN","lastEdited":1786331470203,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"fef58ab9-5597-4415-828a-96b50b8bbaa3","codeSystem":"MESH","code":"C052753","type":"PRIMARY","url":"http://www.ncbi.nlm.nih.gov/mesh/67052753","_isClassification":false,"references":["0caf62c3-c444-4e01-8451-dae62c68ad7b"],"access":[]}],"notes":[{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470210,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"9cc19217-b2ad-4df1-b47f-0dbdf1f336d1","note":"[Validation]WARNING:This fragment is present as a separate record in the database but in a different form. Please register: C1C[C@H]([C@@H](CNC[C@H]([C@@H]2CCc3cc(ccc3O2)F)O)O)Oc4ccc(cc14)F as an individual substance","references":["375a608b-a93b-410c-868a-1a4424e5feac"],"access":["admin"]}],"properties":[],"relationships":[{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0462cba6-0183-4c8f-8919-0bdad5ff5605","amount":{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"26080c91-c884-4db1-b448-c79c57472395","references":[],"access":[]},"relatedSubstance":{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"3882b08c-a848-471f-8c50-1989f99d8184","refPname":"Nebivolol","refuuid":"e933eb1a-38e7-4873-aea6-f2e21fdbf8b7","substanceClass":"reference","approvalID":"030Y90569U","name":"Nebivolol","linkingID":"030Y90569U","references":[],"access":[]},"originatorUuid":"0462cba6-0183-4c8f-8919-0bdad5ff5605","type":"ACTIVE MOIETY","references":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"6e553546-764f-457f-8b2f-c2aee71f7f97","amount":{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"af7331e0-17d6-4859-8245-42976d9245ad","references":[],"access":[]},"relatedSubstance":{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"de7e8f93-bf85-4c2a-80d7-dcc7599053a5","refPname":"N-nitroso-nebivolol","refuuid":"5a8ece8d-549e-49df-9b67-cd62ab0ecf78","substanceClass":"reference","approvalID":"PVJ4BYF656","name":"N-nitroso-nebivolol","linkingID":"PVJ4BYF656","references":[],"access":[]},"originatorUuid":"280ed960-19b4-451a-ac65-6751ab3b69a7","type":"IMPURITY->PARENT","references":["51b99f7b-9323-4e10-a981-45e83e62150a"],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"7bce4d94-312d-459b-8da9-da32f30a4630","amount":{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"9c8c502d-476f-44c4-b99c-376d3d1ef984","references":[],"access":[]},"relatedSubstance":{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"9639cc75-9d7a-4109-a719-898a471063d6","refPname":"Nebivolol","refuuid":"e933eb1a-38e7-4873-aea6-f2e21fdbf8b7","substanceClass":"reference","approvalID":"030Y90569U","name":"Nebivolol","linkingID":"030Y90569U","references":[],"access":[]},"originatorUuid":"7bce4d94-312d-459b-8da9-da32f30a4630","type":"PARENT->SALT/SOLVATE","references":[],"access":[]}],"references":[{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0980b947-a3c6-4cfb-856e-d05fa6e8af8b","citation":"USP DICTIONARY 2010","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN","PUBLIC_DOMAIN_RELEASE","AUTO_SELECTED"],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"098905d0-13bd-799f-46d6-d31d8895b8ef","citation":"USAN COUN 2004","docType":"USANCOUN","publicDomain":true,"tags":["NOMEN","PUBLIC_DOMAIN_RELEASE"],"uploadedFile":"http://gsrs.fda.gov/ginas/app/api/v1/payload(15e98bdb-fa19-49f3-b8fc-7cf2ca4d6911)?format=raw","access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0caf62c3-c444-4e01-8451-dae62c68ad7b","citation":"SRS CODE IMPORT","docType":"FDA_SRS","documentDate":1493404863000,"publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"18bc912e-1838-4870-ab5b-40fa54bb59bf","citation":"STN","docType":"STN (SCIFINDER)","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"1fcf8df3-2442-4e8f-867a-029f4d6b23b7","citation":"WHO-DD","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"32ac6360-04a6-57bf-c3e9-e1d67fd9b667","citation":"DailyMed","docType":"DAILYMED","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"375a608b-a93b-410c-868a-1a4424e5feac","citation":"GSRS System-generated Validation messages","docType":"VALIDATION_MESSAGE","documentDate":1786331470189,"publicDomain":false,"tags":[],"access":["admin"]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"386e8ce0-56cf-444f-9545-368a673bb262","citation":"USP DICTIONARY 2011","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4423e931-6b20-4150-8226-d71eedc2ed19","citation":"EP monograph","docType":"EP","publicDomain":true,"tags":[],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"48f2f16b-9aa7-4abb-a7ea-7ea9efe32460","citation":"ORANGE BOOK 2011","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4c696a42-7237-00e5-173b-0e172a48d68b","docType":"SYSTEM","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"51b99f7b-9323-4e10-a981-45e83e62150a","citation":"Updated Information | Recommended Acceptable Intake Limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs); Table 1","docType":"WEB PAGE","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"url":"https://www.fda.gov/regulatory-information/search-fda-guidance-documents/updated-information-recommended-acceptable-intake-limits-nitrosamine-drug-substance-related","access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"57370dfb-50f1-d378-7dbd-c118b96d1450","citation":"WHO-DD","docType":"WHO DRUG DICTIONARY","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"58e95db9-f575-4238-aff2-f923f5725c6a","citation":"MERCK","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"5d3825b4-3af0-4d22-aa1d-46b26c297ae7","citation":"Updated Information | Recommended Acceptable Intake Limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs); Table 1","docType":"WEB PAGE","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"url":"https://www.fda.gov/regulatory-information/search-fda-guidance-documents/updated-information-recommended-acceptable-intake-limits-nitrosamine-drug-substance-related","access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"660c4ee5-b753-47ee-8368-ff82401e91c4","citation":"USP DICTIONARY","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"724d6646-1c64-997e-6ba6-8b5f0113d758","citation":"EU-SRS","docType":"EMA LIST","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"74f49e0c-d0b1-99e5-6fd8-fcc627c44c49","citation":"USAD COUN","docType":"USANCOUN","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"86f5371c-220c-4fa3-986b-745cfcc2f5f9","citation":"NEBIVOLOL HYDROCHLORIDE [ORANGE BOOK]","docType":"SRS_LOCATOR","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"886b02ad-450d-4a18-904d-82191ea2cb77","citation":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4ad6a5b-e69d-4b39-9fe3-58569a964978","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4ad6a5b-e69d-4b39-9fe3-58569a964978","access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"8c605a24-be38-41cc-803e-e8e9ff8b3b30","citation":"NEBIVOLOL HYDROCHLORIDE [MI]","docType":"SRS_LOCATOR","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"acc51950-fc30-4837-bd8a-9f30720c99ab","citation":"NEBIVOLOL HYDROCHLORIDE [USAN]","docType":"SRS_LOCATOR","publicDomain":true,"tags":[],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b06d3d47-bbe2-4669-b367-be72323662a5","citation":"MARTINDALE 2011","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b0c1fff4-bbc8-4972-9b6d-8f2378f8219e","citation":"USP DICTIONARY 2008","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"c5873edd-11f5-4cd5-91b9-9a5390968a92","citation":"ORANGE BOOK","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"c63df0a6-ac47-9f9f-3425-654a94d15aa4","citation":"USP-RS","docType":"USPNF","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"cdd94218-9f53-4d1d-b658-6c547595577b","citation":"NEBIVOLOL HYDROCHLORIDE [MART.]","docType":"SRS_LOCATOR","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"d0b43f17-5db0-4a65-bc5d-078e2b62fbe7","citation":"NEBIVOLOL HYDROCHLORIDE [WHO-DD]","docType":"SRS_LOCATOR","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"d2e447a7-95bf-a128-748a-e74f6c4ef789","citation":"PUBCHEM","docType":"PUBCHEM","publicDomain":true,"tags":[],"access":[]},{"created":1786331470205,"createdBy":"ADMIN","lastEdited":1786331470205,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"e5a4d6a5-7153-41be-8eb6-414cbbd65bec","citation":"SRS import [JGS34J7L9I]","docType":"FDA_SRS","documentDate":1493404863000,"publicDomain":true,"tags":["NOMEN"],"url":"http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=JGS34J7L9I","access":[]},{"created":1786331470204,"createdBy":"ADMIN","lastEdited":1786331470204,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"ec8341f2-01bf-46da-91f8-dda24a52141c","citation":"FDA-SRS 2010","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"access":[]}],"approvalID":"JGS34J7L9I","tags":[],"structure":{"id":"79a1f637-2daa-4111-8895-1ae2f58513e8","created":1786331470200,"lastEdited":1786331470209,"deprecated":false,"digest":"9bf64ba26572f420f84bc74a701bedacf05d23c4","molfile":"\n   JSDraw209112520172D\n\n 30 32  0  0  0  0              0 V2000\n   25.1680   -8.4759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   27.8699   -8.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   26.5191   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   29.2210   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   29.2210   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   30.5720   -5.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   31.9231   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   33.2739   -5.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   34.6249   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   34.6249   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   33.2739   -8.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   31.9231   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   30.5720   -8.4759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   35.9760   -5.3561    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0\n   27.8699  -10.0359    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   22.4661   -8.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   23.8169   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   21.1150   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   21.1150   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   19.7640   -5.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.4129   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   17.0621   -5.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   15.7111   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   15.7111   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   17.0621   -8.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.4129   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   19.7640   -8.4759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   14.3600   -5.3561    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0\n   22.4661  -10.0359    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   36.4520  -10.5040    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0\n  2  3  1  0  0  0  0\n  4  5  1  0  0  0  0\n  5  6  1  0  0  0  0\n  6  7  1  0  0  0  0\n  7  8  1  0  0  0  0\n  8  9  2  0  0  0  0\n  9 10  1  0  0  0  0\n 10 11  2  0  0  0  0\n 11 12  1  0  0  0  0\n  7 12  2  0  0  0  0\n 12 13  1  0  0  0  0\n  4 13  1  1  0  0  0\n  9 14  1  0  0  0  0\n  2  4  1  0  0  0  0\n  2 15  1  6  0  0  0\n  1  3  1  0  0  0  0\n 16 17  1  0  0  0  0\n 18 19  1  0  0  0  0\n 19 20  1  0  0  0  0\n 20 21  1  0  0  0  0\n 21 22  1  0  0  0  0\n 22 23  2  0  0  0  0\n 23 24  1  0  0  0  0\n 24 25  2  0  0  0  0\n 25 26  1  0  0  0  0\n 21 26  2  0  0  0  0\n 26 27  1  0  0  0  0\n 18 27  1  1  0  0  0\n 23 28  1  0  0  0  0\n 16 18  1  0  0  0  0\n 16 29  1  1  0  0  0\n  1 17  1  0  0  0  0\nM  END","smiles":"C1C[C@H]([C@@H](CNC[C@H]([C@@H]2CCc3cc(ccc3O2)F)O)O)Oc4ccc(cc14)F.Cl","formula":"C22H25F2NO4.ClH","opticalActivity":"( + / - )","atropisomerism":"No","stereoCenters":4,"definedStereo":4,"ezCenters":0,"charge":0,"mwt":441.8967,"count":1,"createdBy":"ADMIN","lastEditedBy":"ADMIN","stereochemistry":"RACEMIC","access":[],"references":["0980b947-a3c6-4cfb-856e-d05fa6e8af8b","e5a4d6a5-7153-41be-8eb6-414cbbd65bec"],"_inchiKey":"JWEXHQAEWHKGCW-VCVZPGOSSA-N","_inchi":"InChI=1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/m1./s1","hash":"JWEXHQAEWHKGCW_VCVZPGOSSA_N"},"moieties":[{"created":1786331470206,"createdBy":"ADMIN","lastEdited":1786331470210,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"27c3edb2-c82b-4744-b995-a8910045fc1d","id":"27c3edb2-c82b-4744-b995-a8910045fc1d","digest":"89cf5b944f9f3b49052ce566e6b693ba430903b2","molfile":"\n  CDK     09112520172D\n\n  1  0  0  0  0  0  0  0  0  0999 V2000\n   36.4520  -10.5040    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0\nM  END","smiles":"Cl","formula":"ClH","opticalActivity":"NONE","atropisomerism":"No","stereoCenters":0,"definedStereo":0,"ezCenters":0,"charge":0,"mwt":36.4609,"count":1,"stereochemistry":"ACHIRAL","access":[],"references":[],"_inchiKey":"VEXZGXHMUGYJMC-UHFFFAOYSA-N","_inchi":"InChI=1S/ClH/h1H","hash":"VEXZGXHMUGYJMC_UHFFFAOYSA_N","countAmount":{"created":1786331470206,"createdBy":"ADMIN","lastEdited":1786331470206,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"762f2d53-ce1f-4a64-902e-81897e9d2036","type":"MOL RATIO","average":1.0,"units":"MOL RATIO","references":[],"access":[]}},{"created":1786331470207,"createdBy":"ADMIN","lastEdited":1786331470210,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"ea8a1f99-c70c-4fe6-8bcc-abca622edd32","id":"ea8a1f99-c70c-4fe6-8bcc-abca622edd32","digest":"3c846f516fc2dc482053371af0ebe19e069fce0d","molfile":"\n  CDK     09112520172D\n\n 29 32  0  0  1  0  0  0  0  0999 V2000\n   25.1680   -8.4759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   27.8699   -8.4759    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0\n   26.5191   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   29.2210   -7.6961    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0\n   29.2210   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   30.5720   -5.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   31.9231   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   33.2739   -5.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   34.6249   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   34.6249   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   33.2739   -8.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   31.9231   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   30.5720   -8.4759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   35.9760   -5.3561    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0\n   27.8699  -10.0359    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   22.4661   -8.4759    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0\n   23.8169   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   21.1150   -7.6961    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0\n   21.1150   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   19.7640   -5.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.4129   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   17.0621   -5.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   15.7111   -6.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   15.7111   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   17.0621   -8.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.4129   -7.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   19.7640   -8.4759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   14.3600   -5.3561    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0\n   22.4661  -10.0359    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n  2  3  1  0  0  0  0\n  4  5  1  0  0  0  0\n  5  6  1  0  0  0  0\n  6  7  1  0  0  0  0\n  7  8  1  0  0  0  0\n  8  9  2  0  0  0  0\n  9 10  1  0  0  0  0\n 10 11  2  0  0  0  0\n 11 12  1  0  0  0  0\n  7 12  2  0  0  0  0\n 12 13  1  0  0  0  0\n  4 13  1  1  0  0  0\n  9 14  1  0  0  0  0\n  2  4  1  0  0  0  0\n  2 15  1  6  0  0  0\n  1  3  1  0  0  0  0\n 16 17  1  0  0  0  0\n 18 19  1  0  0  0  0\n 19 20  1  0  0  0  0\n 20 21  1  0  0  0  0\n 21 22  1  0  0  0  0\n 22 23  2  0  0  0  0\n 23 24  1  0  0  0  0\n 24 25  2  0  0  0  0\n 25 26  1  0  0  0  0\n 21 26  2  0  0  0  0\n 26 27  1  0  0  0  0\n 18 27  1  1  0  0  0\n 23 28  1  0  0  0  0\n 16 18  1  0  0  0  0\n 16 29  1  1  0  0  0\n  1 17  1  0  0  0  0\nM  END","smiles":"C1C[C@H]([C@@H](CNC[C@H]([C@@H]2CCc3cc(ccc3O2)F)O)O)Oc4ccc(cc14)F","formula":"C22H25F2NO4","opticalActivity":"UNSPECIFIED","atropisomerism":"No","stereoCenters":4,"definedStereo":4,"ezCenters":0,"charge":0,"mwt":405.4358,"count":1,"stereochemistry":"ABSOLUTE","access":[],"references":[],"_inchiKey":"KOHIRBRYDXPAMZ-YHBROIRLSA-N","_inchi":"InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22+/m1/s1","hash":"KOHIRBRYDXPAMZ_YHBROIRLSA_N","countAmount":{"created":1786331470207,"createdBy":"ADMIN","lastEdited":1786331470207,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"22b06857-5881-4339-869f-f6225f9e19d9","type":"MOL RATIO","average":1.0,"units":"MOL RATIO","references":[],"access":[]}}],"_name":"Nebivolol hydrochloride","_approvalIDDisplay":"JGS34J7L9I","access":[],"_self":"https://gsrs.ncats.nih.gov/api/v1/substances(21a0f610-ab27-4d76-afca-610b7abc040c)?view=full"}