{"created":1786388918972,"createdBy":"ADMIN","lastEdited":1786388918972,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"165dbb98-57f3-4152-98b5-a68cd8ccd1d3","definitionType":"PRIMARY","definitionLevel":"COMPLETE","substanceClass":"protein","status":"approved","version":"12","approvedBy":"FDA_SRS","names":[{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"91c1b43a-6624-4e49-5232-508419a5316a","name":"CATHELICIDIN LL 37 (HUMAN)","stdName":"CATHELICIDIN LL 37 (HUMAN)","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["e2555d4c-5853-6ca2-5371-144bb6612cde"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"d73d4eaf-8e24-7da5-3501-2002f92ea68a","name":"CATHELICIDIN LL-37","stdName":"CATHELICIDIN LL-37","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["e2555d4c-5853-6ca2-5371-144bb6612cde"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"5ce9ebc5-dd0c-b1b5-c659-0b841682c3c1","name":"L-SERINE, L-LEUCYL-L-LEUCYLGLYCYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANYL-L-PHENYLALANYL-L-ARGINYL-L-LYSYL-L-SERYL-L-LYSYL-L-.ALPHA.-GLUTAMYL-L-LYSYL-L-ISOLEUCYLGLYCYL-L-LYSYL-L-.ALPHA.-GLUTAMYL-L-PHENYLALANYL-L-LYSYL-L-ARGINYL-L-ISOLEUCYL-L-VALYL-L-GLUTAMINYL-L-ARGINYL-L-ISOLEUCYL-L-LYSYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANYL-L-LEUCYL-L-ARGINYL-L-ASPARAGINYL-L-LEUCYL-L-VALYL-L-PROLYL-L-ARGINYL-L-THREONYL-L-.ALPHA.-GLUTAMYL-","stdName":"L-SERINE, L-LEUCYL-L-LEUCYLGLYCYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANYL-L-PHENYLALANYL-L-ARGINYL-L-LYSYL-L-SERYL-L-LYSYL-L-.ALPHA.-GLUTAMYL-L-LYSYL-L-ISOLEUCYLGLYCYL-L-LYSYL-L-.ALPHA.-GLUTAMYL-L-PHENYLALANYL-L-LYSYL-L-ARGINYL-L-ISOLEUCYL-L-VALYL-L-GLUTAMINYL-L-ARGINYL-L-ISOLEUCYL-L-LYSYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANYL-L-LEUCYL-L-ARGINYL-L-ASPARAGINYL-L-LEUCYL-L-VALYL-L-PROLYL-L-ARGINYL-L-THREONYL-L-.ALPHA.-GLUTAMYL-","type":"sys","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["e2555d4c-5853-6ca2-5371-144bb6612cde"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"17d99844-9ad7-475e-9840-af9766d1a9df","name":"LEU-LEU-GLY-ASP-PHE-PHE-ARG-LYS-SER-LYS-GLU-LYS-ILE-GLY-LYS-GLU-PHE-LYS-ARG-ILE-VAL-GLN-ARG-ILE-LYS-ASP-PHE-LEU-ARG-ASN-LEU-VAL-PRO-ARG-THR-GLU-SER","stdName":"LEU-LEU-GLY-ASP-PHE-PHE-ARG-LYS-SER-LYS-GLU-LYS-ILE-GLY-LYS-GLU-PHE-LYS-ARG-ILE-VAL-GLN-ARG-ILE-LYS-ASP-PHE-LEU-ARG-ASN-LEU-VAL-PRO-ARG-THR-GLU-SER","type":"sys","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["e2555d4c-5853-6ca2-5371-144bb6612cde"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"917e9e60-b9f5-4ec8-b5e6-e4c96d5508fe","name":"LL-37","stdName":"LL-37","type":"cd","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":true,"displayName":false,"references":["9a54772b-fda4-4d41-812d-deae7812dd39","4eb6ca59-5d26-4594-ad92-b402d9fc9ac5"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"d5473e52-674c-9672-9b94-d45250b443af","name":"PROTEIN CAP 18 (RABBIT CATIONIC ANTIMICROBIAL 37-AMINO ACID FRAGMENT)","stdName":"PROTEIN CAP 18 (RABBIT CATIONIC ANTIMICROBIAL 37-AMINO ACID FRAGMENT)","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["e2555d4c-5853-6ca2-5371-144bb6612cde"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"48b23fa5-95cd-9fc5-c759-a67339fd3b78","name":"ROPOCAMPTIDE","stdName":"ROPOCAMPTIDE","type":"of","domains":["drug"],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"6dd77285-12f4-48e0-a18d-9e46c38c887e","nameOrg":"INN","references":[],"access":[]}],"preferred":false,"displayName":true,"references":["1ce254af-adf1-5c43-47fd-a1f041f3ad91"],"access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"3dfb04e2-96f9-fe80-bdac-b07e1ef06808","name":"ropocamptide [INN]","stdName":"ROPOCAMPTIDE [INN]","type":"cn","domains":[],"languages":["en"],"nameJurisdiction":[],"nameOrgs":[],"preferred":false,"displayName":false,"references":["1ce254af-adf1-5c43-47fd-a1f041f3ad91"],"access":[]}],"codes":[{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0eb3565e-6015-4e31-a73d-361c6a8ee3e0","codeSystem":"PUBCHEM","code":"16198951","type":"PRIMARY","url":"https://pubchem.ncbi.nlm.nih.gov/compound/16198951","_isClassification":false,"references":["8c73ad77-39db-4341-83cc-ff94f82d580a"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"13796888-659c-b306-5759-751d8e623c65","codeSystem":"NCI_THESAURUS","code":"C129820","comments":"Pharmacologic Substance[C1909]|Immunotherapeutic Agent[C308]|Antineoplastic Immunomodulating Agent","type":"CONCEPT","url":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C129820","_isClassification":true,"references":["99e8083b-c71f-d750-ceaf-df4ee982933a"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"2ade59d0-3009-46d0-90aa-bd23a7956bf0","codeSystem":"INN","code":"11051","type":"PRIMARY","url":"https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=11051","_isClassification":false,"references":["1ce254af-adf1-5c43-47fd-a1f041f3ad91"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"2c928c13-8a5d-7316-fea2-1ddcaf9caccb","codeSystem":"NCI_THESAURUS","code":"C118292","type":"PRIMARY","url":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C118292","_isClassification":false,"references":["99e8083b-c71f-d750-ceaf-df4ee982933a"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"304cd09b-4b57-fede-a258-6844a8e7efcd","codeSystem":"SMS_ID","code":"300000010883","type":"PRIMARY","_isClassification":false,"references":["18f33056-351a-1a1b-8f47-5489bba2d263"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"619c972d-849b-bdbb-4e4c-14d682e7c1a0","codeSystem":"NCI_THESAURUS","code":"C129821","comments":"Pharmacologic Substance[C1909]|Biological Agent[C307]|Antineoplastic Biological Agent","type":"CONCEPT","url":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C129821","_isClassification":true,"references":["99e8083b-c71f-d750-ceaf-df4ee982933a"],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"8eca41c0-4c6a-40a1-9ae6-ffe6581148bf","codeSystem":"FDA UNII","code":"3DD771JO2H","type":"PRIMARY","_isClassification":false,"references":[],"access":[]},{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"c5765f4a-f76b-4926-9d81-79c9f949e599","codeSystem":"CAS","code":"154947-66-7","type":"PRIMARY","url":"https://commonchemistry.cas.org/detail?cas_rn=154947-66-7","_isClassification":false,"references":["8c73ad77-39db-4341-83cc-ff94f82d580a","39dbe585-78a5-4d64-878f-aa0bd717c978"],"access":[]}],"modifications":{"created":1786388918973,"createdBy":"ADMIN","lastEdited":1786388918973,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"69cb71ac-60f0-48ff-b750-573a9d3f8d1c","agentModifications":[],"physicalModifications":[],"structuralModifications":[],"references":[],"access":[]},"notes":[],"properties":[{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"8123bbb3-2170-4907-946c-bcfe66be640b","name":"Molecular Formula","propertyType":"CHEMICAL","value":{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"e1a096a5-a339-48c8-8744-579be3a189b8","type":"ESTIMATED","nonNumericValue":"C205H339N60O53","references":[],"access":[]},"defining":false,"parameters":[],"references":[],"access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"cbc92b33-4cd1-48d3-a967-1a345cb9bcae","name":"MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)","type":"amount","propertyType":"CHEMICAL","value":{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"63791c14-6f9e-4adb-add3-79535199363e","type":"NUMBER AVERAGE","average":4493.0,"units":"DA","references":[],"access":[]},"defining":false,"parameters":[],"references":[],"access":[]}],"relationships":[{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"203d116e-e22f-4baf-a6c1-c847e6ce94a2","amount":{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"0ebc5d55-bdd6-48c1-a7d4-9077f22799e1","references":[],"access":[]},"relatedSubstance":{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"cb618e30-e9f5-4cc3-9651-8bc9aa2c5906","refPname":"ROPOCAMPTIDE","refuuid":"165dbb98-57f3-4152-98b5-a68cd8ccd1d3","substanceClass":"reference","approvalID":"3DD771JO2H","name":"ROPOCAMPTIDE","linkingID":"3DD771JO2H","references":[],"access":[]},"originatorUuid":"203d116e-e22f-4baf-a6c1-c847e6ce94a2","type":"ACTIVE MOIETY","references":["e2555d4c-5853-6ca2-5371-144bb6612cde"],"access":[]}],"references":[{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"18f33056-351a-1a1b-8f47-5489bba2d263","citation":"SMS","docType":"EMA LIST","publicDomain":true,"tags":[],"access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"1ce254af-adf1-5c43-47fd-a1f041f3ad91","citation":"INN Proposed List 121","docType":"INN_LIST","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE"],"url":"https://www.who.int/medicines/publications/druginformation/innlists/PL121.pdf","access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"39dbe585-78a5-4d64-878f-aa0bd717c978","citation":"STN","docType":"STN (SCIFINDER)","publicDomain":true,"tags":[],"access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4cb84516-c5c5-d9b5-cb19-d1a48fa566ca","citation":"DailyMed","docType":"DAILYMED","publicDomain":true,"tags":[],"access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"4eb6ca59-5d26-4594-ad92-b402d9fc9ac5","citation":"CLINICALTRIALS","docType":"CLINICALTRIALS","publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"7fbf158b-cea1-4363-8065-ee80fb3fc53e","citation":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432748/","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN"],"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432748/","access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"8c73ad77-39db-4341-83cc-ff94f82d580a","citation":"SRS CODE IMPORT","docType":"FDA_SRS","documentDate":1493407456000,"publicDomain":true,"tags":["NOMEN"],"access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"99e8083b-c71f-d750-ceaf-df4ee982933a","docType":"SYSTEM","publicDomain":true,"tags":[],"access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"9a54772b-fda4-4d41-812d-deae7812dd39","citation":" 154947-66-7","docType":"FDA_SRS","publicDomain":true,"tags":["NOMEN","PUBLIC_DOMAIN_RELEASE","AUTO_SELECTED"],"access":[]},{"created":1786388918975,"createdBy":"ADMIN","lastEdited":1786388918975,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"e2555d4c-5853-6ca2-5371-144bb6612cde","citation":"stn","docType":"STN (SCIFINDER)","publicDomain":true,"tags":["PUBLIC_DOMAIN_RELEASE","NOMEN"],"access":[]}],"approvalID":"3DD771JO2H","tags":[],"protein":{"created":1786388918973,"createdBy":"ADMIN","lastEdited":1786388919115,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"bb91e47d-e292-4ea2-8c37-a4293b846388","proteinSubType":"","sequenceType":"COMPLETE","glycosylation":{"created":1786388918973,"createdBy":"ADMIN","lastEdited":1786388918973,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"f238f4cd-d1fb-4ce2-a57c-f9177826af0b","NGlycosylationSites":[],"OGlycosylationSites":[],"CGlycosylationSites":[],"references":[],"access":[]},"subunits":[{"created":1786388918974,"createdBy":"ADMIN","lastEdited":1786388918974,"lastEditedBy":"ADMIN","deprecated":false,"uuid":"b01c28a1-edd3-4834-bd16-8d7d6c5eff78","sequence":"LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES","subunitIndex":1,"length":37,"references":[],"access":[]}],"otherLinks":[],"disulfideLinks":[],"references":["7fbf158b-cea1-4363-8065-ee80fb3fc53e","1ce254af-adf1-5c43-47fd-a1f041f3ad91"],"access":[]},"_name":"ROPOCAMPTIDE","_approvalIDDisplay":"3DD771JO2H","access":[],"_self":"https://gsrs.ncats.nih.gov/api/v1/substances(165dbb98-57f3-4152-98b5-a68cd8ccd1d3)?view=full"}